Boehmite Enhances Hair Follicle Growth via Stimulation of Dermal Papilla Cells by Upregulating Beta-Catenin Signaling

    October 2019 in “ Experimental Dermatology
    Dong‐Ho Bak, Esther Lee, Byung‐Chul Lee, Mi Ji Choi, Tae‐Rin Kwon, Jong Hwan Kim, Byung Cheol Park, Keugrae Lee, Sungyup Kim, Jungtae Na, Beom Joon Kim
    TLDR Boehmite promotes hair growth by stimulating key cells and pathways.
    The study investigated the effects of boehmite on hair growth, revealing that it enhanced hair follicle growth by stimulating human dermal papilla cells (hDPCs) and upregulating β-catenin signaling. In vitro and in vivo experiments showed dose-dependent proliferation of hDPCs and hair regrowth in a mouse model. Boehmite increased hDPC viability, alkaline phosphatase activity, AKT/GSK3ß/ß-catenin pathway activity, anagen-related gene expression, and VEGF secretion. It also accelerated hair regrowth during the catagen-anagen transition, indicating its potential as a therapeutic agent for promoting hair growth by affecting critical events in the active phase of the hair follicle cycle.
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