Boehmite Enhances Hair Follicle Growth via Stimulation of Dermal Papilla Cells by Upregulating Beta-Catenin Signaling

    October 2019 in “ Experimental Dermatology
    Dong‐Ho Bak, Esther Lee, Byung‐Chul Lee, Mi Ji Choi, Tae‐Rin Kwon, Jong Hwan Kim, Byung Cheol Park, Keugrae Lee, Sungyup Kim, Jungtae Na, Beom Joon Kim
    TLDR Boehmite promotes hair growth by stimulating key cells and pathways.
    The study investigated the effects of boehmite on hair follicle growth, focusing on its impact on human dermal papilla cells (hDPCs) and hair regrowth in a mouse model. Boehmite was found to enhance hDPC viability, alkaline phosphatase activity, and vascular endothelial growth factor secretion, while also activating the AKT/GSK3β/β-catenin signaling pathway. These effects promoted the transition of hair follicles to the anagen phase, leading to accelerated hair regrowth. The findings suggested that boehmite could stimulate hair growth by promoting the proliferation of hDPCs and their progeny, highlighting its potential as a therapeutic agent for hair loss.
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