The Effects of Centipedegrass Extract on Hair Growth via Promotion of Anagen Inductive Activity

    March 2022 in “ PLoS ONE
    Fatuma Ramadhani, Dong‐Ho Bak, Seong Hee Kang, Chul‐Hong Park, Sanghwa Park, Byung Yeoup Chung, Hyoung‐Woo Bai
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    TLDR Centipedegrass extract may promote hair growth by activating certain cell pathways.
    The study investigated the effects of centipedegrass extract (CGE) on hair growth by examining its impact on human hair dermal papilla cells (hDPCs) and keratinocytes (HaCaT cells), as well as its application on C57BL/6 mice. CGE was found to increase cell viability, ALP activity, and the expression of several genes and proteins related to hair growth, such as CTNNB1, ALP, SOX2, IGF1, and VEGFA in hDPCs. It also enhanced the AKT-ERK-GSKβ-β-catenin signaling pathway in HaCaT cells. The topical application of CGE on mice confirmed its ability to promote the transition from the telogen to anagen phase, suggesting that CGE could be a potential therapeutic agent for promoting hair growth by activating β-catenin signaling pathways.
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