Synthesized Ceramide Induces Growth of Dermal Papilla Cells with Potential Contribution to Hair Growth

January 2019 in “ Annals of dermatology/Annals of Dermatology ”

Jee Hye Oh, Kwan Jeong, Jung Eun Kim, Hoon Kang

synthetic ceramides oleyl ceramide stearyl ceramide human dermal papilla cells hDPCs Bcl-2 BAX phosphorylated-ERK Cyclin D1 epidermal growth factor family Wnt/β-catenin signaling pathway BMP2 signaling pathway BMP4 signaling pathway ceramides growth factors Wnt signaling BMP signaling

TLDR Synthetic ceramides may help hair growth by boosting cell growth in hair follicles.

The study investigated the effects of synthetic ceramides (oleyl and stearyl ceramides) on human dermal papilla cells (hDPCs), which are crucial for hair growth. The results showed that ceramide treatment increased cell viability and the expression of proteins related to cell proliferation, such as Bcl-2, BAX, phosphorylated-ERK, and Cyclin D1. Additionally, ceramides enhanced the expression of several growth factors, including those from the epidermal growth factor family, and promoted Wnt/β-catenin and BMP2/4 signaling pathways. These findings suggested that synthetic ceramides could stimulate hair growth by inducing the proliferation of hDPCs through these signaling pathways.

View this study on anndermatol.org →

Discuss this study in the Community →

Research cited in this study

10 / 10 results

research Promotion of Hair Growth by Newly Synthesized Ceramide Mimetic Compound

8 citations, July 2017 in “Biochemical and biophysical research communications”

A new compound, BOI, can help hair grow by changing hair cycle phases and increasing certain cell contents.

research Effect of Mycophenolic Acid on Proliferation of Dermal Papilla Cells and Induction of Anagen Hair Follicles

16 citations, March 2015 in “Clinical and experimental dermatology”

Mycophenolic acid may help treat hair loss by promoting hair growth and cell proliferation.

research Age-Dependent Changes in Damage Processes of Hair Cuticle

20 citations, January 2015 in “Journal of cosmetic dermatology”

Older people's hair cuticles get more easily damaged and lose protective oils, especially in their 40s and 50s.

research Signaling Involved in Hair Follicle Morphogenesis and Development

223 citations, January 2014 in “International Journal of Molecular Sciences”

The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.

research Damaged Hair Retrieval with Ceramide-Rich Liposomes

2 citations, June 2012 in “PubMed”

Ceramide-rich liposomes can effectively repair and strengthen damaged hair.

research Minoxidil Activates β-Catenin Pathway in Human Dermal Papilla Cells: A Possible Explanation for Its Anagen Prolongation Effect

88 citations, February 2011 in “Journal of Dermatological Science”

Minoxidil helps hair growth by activating the β-catenin pathway.

research Oxidative Stress in Aging of Hair

126 citations, January 2009 in “International Journal of Trichology”

Oxidative stress contributes to hair graying and loss as we age.

research Promotion of Hair Follicle Development and Trichogenesis by Wnt-10b in Cultured Embryonic Skin and Reconstituted Skin

27 citations, May 2006 in “Biochemical and Biophysical Research Communications”

Wnt-10b is important for starting hair growth and developing hair follicles.

research Integral Lipid in Human Hair Follicle

30 citations, November 2005 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

The lipid in human hair follicles acts as a barrier, similar to the skin's lipid layer.

research Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle

149 citations, April 2004 in “Journal of Dermatological Science”

Minoxidil boosts hair growth by increasing cell production and survival.

Related Research

6 / 6 results

research Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes

January 2022 in “Journal of St. Marianna University”

Substances from human hair cells can affect hair loss-related genes, potentially leading to new treatments for baldness.

research A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles

15 citations, April 2014 in “Experimental Dermatology”

Scientists developed a system to study human hair growth using skin cells, which could help understand hair development and improve skin substitutes for medical use.

research Review of Hair Follicle Dermal Cells

321 citations, December 2009 in “Journal of Dermatological Science”

Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.

Synthesized Ceramide Induces Growth of Dermal Papilla Cells with Potential Contribution to Hair Growth

Research cited in this study

research Promotion of Hair Growth by Newly Synthesized Ceramide Mimetic Compound

research Effect of Mycophenolic Acid on Proliferation of Dermal Papilla Cells and Induction of Anagen Hair Follicles

research Age-Dependent Changes in Damage Processes of Hair Cuticle

research Signaling Involved in Hair Follicle Morphogenesis and Development

research Damaged Hair Retrieval with Ceramide-Rich Liposomes

research Minoxidil Activates β-Catenin Pathway in Human Dermal Papilla Cells: A Possible Explanation for Its Anagen Prolongation Effect

research Oxidative Stress in Aging of Hair

research Promotion of Hair Follicle Development and Trichogenesis by Wnt-10b in Cultured Embryonic Skin and Reconstituted Skin

research Integral Lipid in Human Hair Follicle

research Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle

Related Community Posts Join

community Lion Mane Part 2: Microneedling with Topicals, beneficial compounds, maybe?

community Countering oral minoxidil side effects by taking collagen supplements?

community Has anyone here tried topical synthetic prostaglandins (Bimatoprost, Latanoprost, cetirizine) to stimulate hair growth?

community ASC-J9: Poor man’s GT-20029 that might work for regrowth. Anyone try this stuff?

community Collagen/Vitamins/Supplements and skin-care routine while on Minoxidil?

community medication for hair loss spironolactone

Related Research

research Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes

research A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles

research Review of Hair Follicle Dermal Cells

research Study on Hair Follicle Formation Induced by Dermal Papilla Cells

research Trans-Species Hair Growth Induction by Human Hair Follicle Dermal Papillae

research Role of Hair Papilla Cells in Induction and Regeneration Processes of Hair Follicles