Synthesized Ceramide Induces Growth of Dermal Papilla Cells with Potential Contribution to Hair Growth

January 2019 in “ Annals of dermatology/Annals of Dermatology ”

Jee Hye Oh, Kwan Jeong, Jung Eun Kim, Hoon Kang

synthetic ceramides oleyl ceramide stearyl ceramide human dermal papilla cells hDPCs Bcl-2 BAX phosphorylated-ERK Cyclin D1 epidermal growth factor family Wnt/β-catenin signaling pathway BMP2 signaling pathway BMP4 signaling pathway ceramides growth factors Wnt signaling BMP signaling

TLDR Synthetic ceramides may help hair growth by boosting cell growth in hair follicles.

The study investigated the effects of synthetic ceramides (oleyl and stearyl ceramides) on human dermal papilla cells (hDPCs), which are crucial for hair growth. The results showed that ceramide treatment increased cell viability and the expression of proteins related to cell proliferation, such as Bcl-2, BAX, phosphorylated-ERK, and Cyclin D1. Additionally, ceramides enhanced the expression of several growth factors, including those from the epidermal growth factor family, and promoted Wnt/β-catenin and BMP2/4 signaling pathways. These findings suggested that synthetic ceramides could stimulate hair growth by inducing the proliferation of hDPCs through these signaling pathways.

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Synthesized Ceramide Induces Growth of Dermal Papilla Cells with Potential Contribution to Hair Growth

Research cited in this study

research Promotion of Hair Growth by Newly Synthesized Ceramide Mimetic Compound

research Effect of Mycophenolic Acid on Proliferation of Dermal Papilla Cells and Induction of Anagen Hair Follicles

research Age-Dependent Changes in Damage Processes of Hair Cuticle

research Signaling Involved in Hair Follicle Morphogenesis and Development

research Competitive Balance of Intrabulge BMP/Wnt Signaling Reveals a Robust Gene Network Ruling Stem Cell Homeostasis and Cyclic Activation

research Damaged Hair Retrieval with Ceramide-Rich Liposomes

research VEGF induces proliferation of human hair follicle dermal papilla cells through VEGFR-2-mediated activation of ERK

research Effect of IGF-I on Hair Growth Is Related to the Anti-Apoptotic Effect of IGF-I and Up-Regulation of PDGF-A and PDGF-B

research Minoxidil Activates β-Catenin Pathway in Human Dermal Papilla Cells: A Possible Explanation for Its Anagen Prolongation Effect

research Oxidative Stress in Aging of Hair

research Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion

research Promotion of Hair Follicle Development and Trichogenesis by Wnt-10b in Cultured Embryonic Skin and Reconstituted Skin

research Integral Lipid in Human Hair Follicle

research Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle

research Differences in Hair Follicle Dermal Papilla Volume Are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses

research Expression of the Bcl-2 Proto-Oncogene in the Cycling Adult Mouse Hair Follicle

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