Integral Lipid in Human Hair Follicle

    November 2005 in “ ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings ”
    Won‐Soo Lee, Tak Heon Oh, Seung Hyun Chun, Soo Young Jeon, Eun Young Lee, Sanghoon Lee, Won-Seok Park, Sungjoo Hwang
    TLDR The lipid in human hair follicles acts as a barrier, similar to the skin's lipid layer.
    Researchers examined the lipid distribution in human hair follicles and found that the integral hair lipid, distinct from sebaceous lipid, was primarily located in the hair cuticle and keratinized inner root sheath. Using transmission electron microscopy with a new fixative (Lee's fixative) and high-performance thin-layer chromatography, they observed numerous lamellar granules near the lipid layer. The chemical composition of this lipid differed from epidermal and sebaceous lipids, suggesting it functions similarly to the epidermal lipid layer as a barrier. They proposed the term "hair barrier" to describe this function.
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