Integral Lipid in Human Hair Follicle

    November 2005 in “ ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings ”
    Won‐Soo Lee, Tak Heon Oh, Seung Hyun Chun, Soo Young Jeon, Eun Young Lee, Sanghoon Lee, Won-Seok Park, Sungjoo Hwang
    TLDR The lipid in human hair follicles acts as a barrier, similar to the skin's lipid layer.
    Researchers examined the lipid distribution in human hair follicles and found that the integral hair lipid, distinct from sebaceous lipid, was primarily located in the hair cuticle and keratinized inner root sheath. Using transmission electron microscopy with a new fixative (Lee's fixative) and high-performance thin-layer chromatography, they observed numerous lamellar granules near the lipid layer. The chemical composition of this lipid differed from epidermal and sebaceous lipids, suggesting it functions similarly to the epidermal lipid layer as a barrier. They proposed the term "hair barrier" to describe this function.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 83 results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  44 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community Loosing hope after not seeing improvement in hair regrowth.

      in Minoxidil  7 upvotes 11 months ago
      A 22-year-old male is not seeing hair regrowth after using minoxidil and finasteride for a year and additional treatments for three months. Suggestions include improving scalp absorption with sea salt and trying a lipid-based solution, microneedling, and possibly switching to dutasteride if no improvement after 1-2 years.

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  43 upvotes 2 months ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

    Similar Research

    5 / 1000+ results