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Glossary Epidermal Layers

multiple strata of cells forming the skin's outermost part

Epidermal layers refer to the multiple strata of cells that make up the outermost part of the skin, known as the epidermis. These layers include, from the deepest to the most superficial, the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum (only in thick skin), and stratum corneum. Each layer has distinct functions, such as cell regeneration, protection against pathogens, and the formation of a barrier to prevent water loss.

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Research

5 / 1000+ results

research Influence of Hair Growth Cycle on Lipid Composition of Mouse Epidermis and Dermis.

6 citations , November 1960 in “Experimental Biology and Medicine”

In this study, despite morphological differences in the hair growth cycle stages, the lipid composition of the epidermis and dermis showed no significant variation, though water content and cholesterol levels differed between these skin layers.

research Integral hair lipid in human hair follicle

36 citations , August 2011 in “Journal of dermatological science”

This article examines the role and composition of integral hair lipids in forming a protective barrier similar to the skin's epidermal lipid layer and reports no new findings about their effects.

research Integral Lipid in Human Hair Follicle

30 citations , November 2005 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

This study discovered that the lipid in human hair follicles is mainly located in the hair cuticle and keratinized inner root sheath, distinct from sebaceous and epidermal lipids, suggesting a potential role as a "hair barrier.

research Loss of ERBB2 and ERBB3 Receptors Impacts Epidermal Differentiation in Mice

July 2024 in “Journal of Investigative Dermatology”

In this animal study, researchers found that the simultaneous deletion of ERBB2 and ERBB3 in mice results in impaired skin differentiation, inflammation, and sebaceous gland alteration, leading to skin lesions, while highlighting potential side effects in cancer therapies targeting these receptors.

research Development of Stratum Corneum Lipid Liposomes for Topical Drug Delivery

July 2026 in “International Journal of Drug Delivery Technology”

This research reported that liposomal systems made from pig-derived skin lipids enhanced finasteride delivery to hair follicles for treating androgenetic alopecia, showing improved drug deposition, hair length, and growth compared to conventional finasteride forms in vitro.

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community Why everyone should be using topical Dutasteride

45 upvotes 3 months ago

Topical Dutasteride, especially in a liposomal base, is recommended for enhanced scalp DHT suppression when used with oral Dutasteride. It is suggested to apply it twice a week for effective results without significant systemic impact.

community My derm said they came up with a new serum that is better then fin? What’s y’all’s thoughts

8 months ago

A new serum claims to enhance hair regrowth by amplifying oxygen delivery, improving the effectiveness of treatments like exosomes and peptides. Users are skeptical, questioning its efficacy compared to established treatments like Minoxidil and Finasteride.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 2 years ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Topical Dutasteride. Does it work?

in Finasteride/Dutasteride 13 upvotes 2 years ago

Topical dutasteride may be effective for hair loss by staying in the scalp and minimizing bloodstream absorption, potentially improving hair results and reducing side effects. The user seeks advice on its effectiveness.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

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learn Lipodermal base

learn Keratin

learn Ceramide EOP

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