Effect of IGF-I on Hair Growth Is Related to the Anti-Apoptotic Effect of IGF-I and Up-Regulation of PDGF-A and PDGF-B

January 2012 in “ Annals of Dermatology ”

Seok-Yong Ahn, Long-Quan Pi, Sungjoo Hwang, Won‐Soo Lee

insulin-like growth factor-I IGF-I anagen phase platelet-derived growth factor PDGF-A PDGF-B catagen phase anti-apoptotic

TLDR IGF-I promotes hair growth by keeping hair follicles in the growth phase longer.

The study found that insulin-like growth factor-I (IGF-I) promoted hair growth by extending the anagen phase and increasing hair growth rate in an organ culture model of 140 hair follicles from 3 individuals. IGF-I enhanced hair growth to 0.10 mm/day compared to 0.08 mm/day in the control group and maintained 70.8% of hair follicles in the anagen phase by day 12, versus 45.8% in controls. This effect was linked to IGF-I's anti-apoptotic properties and the upregulation of platelet-derived growth factors PDGF-A and PDGF-B, preventing hair follicles from entering the catagen phase.

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