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Glossary Anti-apoptotic

molecules prevent programmed cell death, aiding cell survival

Anti-apoptotic refers to the property of certain molecules or proteins that prevent apoptosis, which is the process of programmed cell death. These molecules help cells survive under conditions that would normally trigger their self-destruction, playing a crucial role in tissue development, immune response, and cancer progression.

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Research

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research Effect of IGF-I on Hair Growth Is Related to the Anti-Apoptotic Effect of IGF-I and Up-Regulation of PDGF-A and PDGF-B

72 citations , January 2012 in “Annals of Dermatology”

In this study, IGF-I was shown to enhance human hair follicle growth, maintain the anagen phase, and increase expression of certain growth factors and anti-apoptotic markers.

research Faculty Opinions recommendation of Effect of IGF-I on Hair Growth Is Related to the Anti-Apoptotic Effect of IGF-I and Up-Regulation of PDGF-A and PDGF-B.

January 2016 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

IGF-I helps hair growth by preventing cell death and boosting growth factors.

research Anti-Amnesia-like Effect of Pinus densiflora Extract by Improving Apoptosis and Neuroinflammation on Trimethyltin-Induced ICR Mice

September 2023 in “International journal of molecular sciences”

In this study involving ICR mice, researchers found that Korean red pine bark extract improved cognitive functions impaired by TMT through mechanisms like antioxidant system protection, cholinergic and synaptic support, mitochondrial regulation, and reduction of neuro-inflammation and apoptosis.

research Anti-CXCL4 monoclonal antibody accelerates telogen to anagen transition and attenuates apoptosis of the hair follicle in mice

June 2017 in “Experimental and Therapeutic Medicine”

In a depilated mouse model, this study found that blocking CXCL4 activity with an anti-CXCL4 monoclonal antibody promoted hair growth by inducing an earlier anagen phase, delaying hair follicle regression, and altering expression of genes and proteins related to hair growth and cell proliferation.

Induction of Hair Growth in Hair Follicle Cells and Organ Cultures Upon Treatment with 30 kHz Frequency Inaudible Sound via Cell Proliferation and Antiapoptotic Effects

research Induction of hair growth in hair follicle cells and organ cultures upon treatment with 30 kHz frequency inaudible sound via cell proliferation and antiapoptotic effects

January 2022 in “Biomedical Reports”

This study suggests that inaudible sound at 30 kHz may promote hair growth and inhibit hair loss signals in human dermal papilla cells, indicating potential as a new treatment for androgenic alopecia.

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Community Join

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community Anti-oxidants that reverse hairloss?

86 upvotes 5 years ago

Resveratrol and fisetin, found in red wine and strawberries, may promote hair growth by affecting hair follicle cells. Users discuss various treatments, including natural remedies like saw palmetto and topical applications, with mixed opinions on their effectiveness compared to pharmaceuticals like finasteride.

community Topical caffeine as an adjunct treatment. I think this should be considered.

4 upvotes 3 years ago

Topical caffeine is suggested as a beneficial adjunct treatment for hair growth due to its anti-fibrotic, anti-inflammatory, antioxidant, and other properties. There is skepticism about its effectiveness, especially at low concentrations like in Alpecin liquid.

community A Study I came along by mistake researching (Dutasteride +Pumpkin seed oil ) for every other day use.

16 upvotes 3 months ago

Alternating Dutasteride with pumpkin seed oil may protect the spleen from damage caused by Dutasteride. Pumpkin seed oil's antioxidants help counteract oxidative stress and immune suppression.

community Short Peptides for Hair Loss: anyone tried any of these?

14 upvotes 5 months ago

Various peptides are discussed for treating male pattern baldness, with some available for topical use like GHK-Cu and Ac-KGHK, while others remain in research stages. Users are interested in experiences and sourcing these treatments.

community Minoxidil actually reduces wrinkles

in Research/Science 209 upvotes 1 year ago

Minoxidil may improve or worsen skin quality, with topical forms causing dryness and wrinkles, possibly due to alcohol content, while oral forms have fewer side effects. Some users consider using tretinoin to mitigate negative effects.

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Learn

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learn GHK-Cu

a copper peptide showing promise in both regrowth and reversing gray hair

learn Melatonin

hormone commonly taken for sleep aid has some topical benefits for hair

learn Overview

learn GT20029

What is GT20029 and how does it work as a topical anti-androgen for hair loss? GT20029 is a topical anti-androgen that degrades androgen receptors to combat hair loss.

learn Aminexil

Aminexil: Can I combine it with anti-hair loss shampoos or will it lose effectiveness? You can safely combine Aminexil with anti-hair loss shampoos for enhanced effectiveness.

learn Cetirizine

What makes cetirizine a unique anti-inflammatory option for your scalp? Laboratory work reports that cetirizine lowers PGD2 and other inflammatory mediators, which is why researchers have proposed it for the scalp. There is no approved topical product and the clinical evidence is one small unblinded pilot study in pattern hair loss, so scalp use is off-label and experimental.

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Clinics

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All 77 clinic results →

Experts

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16
Dermatologist
Andi Iryanti, M. Biomed
Indonesia

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Andi Iryanti, M. Biomed