Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice

    November 2017 in “ Scientific Reports ”
    Ramya Lakshmi Rajendran, Prakash Gangadaran, Soon Sun Bak, Ji Min Oh, S Kalimuthu, Ho Won Lee, Se Hwan Baek, Li Zhu, Young Kwan Sung, Shin Young Jeong, Sang‐Woo Lee, Jaetae Lee, Byeong‐Cheol Ahn
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    Studysummary This study found that treatment with mesenchymal stem cell extracellular vesicles enhanced hair growth in mice and stimulated dermal papilla cell activity and growth factor production in vitro.
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    The 2017 study investigated the effects of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) on hair growth, both in vitro and in vivo. In vitro, MSC-EVs were found to increase proliferation and migration of human dermal papilla cells, as well as upregulate growth factors such as VEGF and IGF-1. In vivo, intradermal injections of MSC-EVs into C57BL/6 mice, with a group size of 6 mice for MSC-EV treatment, 5 mice for the PBS control, and 6 mice for the 3% minoxidil positive control, promoted the transition of hair follicles from the telogen phase to the anagen phase, which is indicative of active hair growth. The treatment was comparable to minoxidil and did not cause toxicity. The study concluded that MSC-EVs could be a potential non-toxic treatment for hair regrowth and activating hair follicles to enter the growth phase.
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