Cytoprotective Role of Human Dental Pulp Stem Cell-Conditioned Medium in Chemotherapy-Induced Alopecia
March 2024
in “
Stem cell research & therapy
”
human dental pulp stem cell-conditioned medium DPSC-CM hypoxic conditions H-CM chemotherapy-induced alopecia CIA keratinocyte viability cytotoxicity apoptosis cyclophosphamide CYP hair regrowth carcinoma cell proliferation tumor growth stem cell-conditioned medium hypoxic medium chemotherapy-induced hair loss keratinocyte health cell toxicity cell death hair growth cancer cell growth tumor development
Studysummary This study found that conditioned medium from human dental pulp stem cells (particularly under hypoxic conditions) improved keratinocyte survival and hair regrowth in a chemotherapy-induced alopecia mouse model and did not promote tumor growth, suggesting potential for safe therapeutic use.
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