From Regenerative Dentistry to Regenerative Medicine: Progress, Challenges, and Potential Applications of Oral Stem Cells

The document reviewed the potential of oral stem cells, particularly mesenchymal and epithelial stem cells from dental tissues, in regenerative medicine. These cells demonstrated significant regenerative capabilities for various tissues, including dental, neural, bone, and epithelial tissues. Dental pulp stem cells (DPSCs) and periodontal ligament stem cells (PDLSCs) showed promise in regenerating dental tissues and aiding in neural and bone recovery. However, challenges such as ensuring cell viability, preventing infection, and addressing tumorigenic properties needed to be overcome. The document emphasized the need for further research, including rigorous quantitative analysis and clinical trials, to address safety and efficacy concerns before these stem cells could be widely applied in clinical settings. Additionally, the importance of banking and manufacturing oral stem cells for future therapeutic use was highlighted.