Hypoxia Treatment of Adipose Mesenchymal Stem Cells Promotes the Growth of Dermal Papilla Cells via HIF-1α and ERK1/2 Signaling Pathways

    July 2023 in “ International Journal of Molecular Sciences ”
    Qing Wang, Mei Zhou, Hongyan Zhang … Dongjun Liu
    Studysummary This study found that a hypoxic microenvironment enhanced the proliferation and pluripotency of adipose mesenchymal stem cells, promoting hair follicle formation and upregulating specific growth factors in Arbas Cashmere goats.
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    Research cited in this study 16

    1. Hair Regeneration Using Adipose-Derived Stem Cells PubMed · 2016
    2. Functional Regulation of Adipose-Derived Stem Cells by PDGF-D Stem Cells · 2014
    3. A Role of Placental Growth Factor in Hair Growth Journal of dermatological science · 2014
    4. Transcriptome Sequencing Reveals Differences Between Primary and Secondary Hair Follicle-Derived Dermal Papilla Cells of the Cashmere Goat PLoS ONE · 2013
    5. Generation and Characterization of Multipotent Stem Cells from Established Dermal Cultures PLoS ONE · 2012
    6. VEGF Induces Proliferation of Human Hair Follicle Dermal Papilla Cells Through VEGFR-2-Mediated Activation of ERK Experimental Cell Research · 2012
    7. Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells PLOS ONE · 2012
    8. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    9. Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion Biomedical research · 2010
    10. Hair Growth Promoting Effects of Adipose Tissue-Derived Stem Cells Journal of Dermatological Science · 2009
    11. Human Hair Growth Enhancement In Vitro By Green Tea Epigallocatechin-3-Gallate (EGCG) Phytomedicine · 2006
    12. PDGF Isoforms Induce and Maintain Anagen Phase of Murine Hair Follicles Journal of Dermatological Science · 2006
    13. Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle Journal of Dermatological Science · 2004
    14. Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla Journal of Investigative Dermatology · 2003
    15. Trans-Species Hair Growth Induction by Human Hair Follicle Dermal Papillae Experimental Dermatology · 2001
    16. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001

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