Induction of Vascular Endothelial Growth Factor Messenger Ribonucleic Acid Expression in Stored Micrografts by Aminoguanidine

November 2005 in “ Dermatologic Surgery ”

Walter Krugluger, Wolfgang Rohrbacher, Karl Moser, Claudia Moser, Katharina Laciak, Joerg Hugeneck

Aminoguanidine Vascular Endothelial Growth Factor VEGF hair follicle micrografts outer root sheath cells bFGF IGF-1 AMG basic Fibroblast Growth Factor Insulin-like Growth Factor 1

Studysummary This study found that aminoguanidine induced increased VEGF mRNA expression in stored hair follicle micrografts, suggesting potential for developing growth-promoting storage solutions in hair restoration surgery.

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In 2005, researchers discovered that Aminoguanidine (AMG) could induce a dose-dependent increase in Vascular Endothelial Growth Factor (VEGF) mRNA in stored hair follicle micrografts from 10 patients, without affecting other growth factors like bFGF or IGF-1. This induction was particularly notable in outer root sheath cells, with a 14-fold increase in VEGF mRNA observed. The study suggested that AMG might improve the viability and post-transplant success of hair micrografts by influencing growth factor production during storage, although the clinical implications of these findings required further investigation.

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