TLDR Aminoguanidine increases a specific growth signal in stored hair grafts, which may help them survive better after being transplanted.
In 2005, researchers discovered that Aminoguanidine (AMG) could induce a dose-dependent increase in Vascular Endothelial Growth Factor (VEGF) mRNA in stored hair follicle micrografts from 10 patients, without affecting other growth factors like bFGF or IGF-1. This induction was particularly notable in outer root sheath cells, with a 14-fold increase in VEGF mRNA observed. The study suggested that AMG might improve the viability and post-transplant success of hair micrografts by influencing growth factor production during storage, although the clinical implications of these findings required further investigation.
520 citations,
February 2001 in “Journal of Clinical Investigation” VEGF helps hair grow and determines follicle size by increasing blood vessel growth.
31 citations,
September 1999 in “Dermatologic Surgery” Cooling hair micrografts during transplantation does not improve their survival or growth.
22 citations,
December 1998 in “Dermatologic Surgery” A new storage solution may increase hair transplant graft survival.
9 citations,
September 1997 in “Dermatologic Surgery” The technique of transplanting micrografts in hair restoration surgery is fast, practical, and efficient, minimizing damage to follicles and grafts.
90 citations,
October 1996 in “Dermatologic Clinics” Growth factors are crucial for hair development and could help treat hair diseases.
30 citations,
March 1996 in “British Journal of Dermatology”
4 citations,
June 2022 in “Journal of Cosmetic Dermatology” Multi-peptide factors from fibroblasts may stimulate hair growth by increasing growth factors and β-catenin in hair cells.
January 2007 in “Linchuang pifuke zazhi” 
3 citations,
November 2005 in “Dermatologic Surgery” Aminoguanidine increases a specific growth signal in stored hair grafts, which may help them survive better after being transplanted.
June 2005 in “Key Engineering Materials” Using hydrogels to slowly release growth factors can effectively boost hair growth in mice.
