Expression of Vascular Endothelial Growth Factor, Apoptosis Inhibitors (Survivin and p16) and CCL27 in Alopecia Areata Before and After Diphencyprone Treatment: An Immunohistochemical Study

May 2004 in “ British Journal of Dermatology ”

Oriana Simonetti, Guendalina Lucarini, Maria Luisa Bernardini, C. Simoncini, G. Biagini, Annamaria Offidani

alopecia areata vascular endothelial growth factor VEGF apoptosis inhibitors survivin p16 CCL27 diphencyprone DPC angiogenesis hair follicle keratinocytes endothelial cell viability peribulbar CD4/CD8 ratio AA

TLDR Diphenylcyclopropenone treatment helps hair growth in alopecia areata by promoting blood vessel growth and cell survival.

The study investigated the effects of topical immunotherapy on alopecia areata (AA) by examining the expression of vascular endothelial growth factor (VEGF), apoptosis inhibitors (survivin and p16), and CCL27 before and after treatment with diphencyprone (DPC). It found that the treatment played a significant role in promoting angiogenesis by upregulating VEGF in hair follicle keratinocytes and enhancing survivin to maintain endothelial cell viability. Additionally, the therapy altered the peribulbar CD4/CD8 ratio, bringing it closer to that of normal scalp skin. These findings contributed to understanding the pathogenesis of AA and the mechanisms by which DPC might act in this complex condition.

View this study on academic.oup.com →

Discuss this study in the Community →

Research cited in this study

9 / 9 results

research Alopecia Areata Update

391 citations , January 2010 in “Journal of The American Academy of Dermatology”

Half of people with Alopecia Areata may see hair regrowth within a year without treatment, but recovery is unpredictable.

research Hair Growth Effect of Minoxidil

25 citations , January 2002 in “Folia Pharmacologica Japonica”

Minoxidil helps hair grow by improving blood flow and increasing growth factors in hair follicles.

research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

520 citations , February 2001 in “Journal of Clinical Investigation”

VEGF helps hair grow and determines follicle size by increasing blood vessel growth.

research Alopecia Areata Update

49 citations , April 2000 in “Journal of The American Academy of Dermatology”

Despite progress in treatment, the exact cause of Alopecia areata is still unknown.

research Role of Cytotoxic T Cells in Chronic Alopecia Areata

127 citations , January 2000 in “Journal of Investigative Dermatology”

Cytotoxic T cells cause hair loss in chronic alopecia areata.

research Expression of Vascular Endothelial Growth Factor (VEGF) in Various Compartments of the Human Hair Follicle

105 citations , December 1998 in “Archives of Dermatological Research”

research Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells

192 citations , March 1998 in “British Journal of Dermatology”

Minoxidil boosts growth factor in hair cells, potentially promoting hair growth.

research Loss of Vascular Endothelial Growth Factor in Human Alopecia Hair Follicles

47 citations , May 1995 in “Journal of Investigative Dermatology”

Hair follicles in people with alopecia have lower levels of a key blood vessel growth protein.

research Immunohistochemical and Electron Microscopic Characterization of the Cellular Infiltrate in Alopecia Areata, Totalis, and Universalis

78 citations , July 1984 in “Journal of Investigative Dermatology”

Related Research

8 / 8 results

Hair Follicle-Derived Mesenchymal Stem Cells Decrease Alopecia Areata Mouse Hair Loss and Reduce Inflammation Around the Hair Follicle

research Hair Follicle-Derived Mesenchymal Stem Cells Decrease Alopecia Areata Mouse Hair Loss and Reduce Inflammation Around the Hair Follicle

11 citations , October 2021 in “Stem Cell Research & Therapy”

Hair follicle stem cells reduced hair loss and inflammation in mice with a condition similar to human alopecia.

research Role of Vitamin D in Hair Loss: A Short Review

14 citations , September 2021 in “Journal of Cosmetic Dermatology”

Low vitamin D levels are linked to various types of hair loss, but more research is needed before using it as a treatment.

research The Role of Vitamin D in Non-Scarring Alopecia

32 citations , December 2017 in “International Journal of Molecular Sciences”

Low vitamin D might be linked to certain types of hair loss, and supplements could help, but more research is needed.

research Hematological And Hepatic Effects Of Vascular Epidermal Growth Factor (VEGF) Used To Stimulate Hair Growth In An Animal Model

30 citations , October 2013 in “BMC dermatology”

VEGF gel increases hair growth but may have potential toxicity.

Miniaturized Hairs Maintain Contact With the Arrector Pili Muscle in Alopecia Areata but Not in Androgenetic Alopecia: A Model for Reversible Miniaturization and Potential for Hair Regrowth

research Miniaturized Hairs Maintain Contact With the Arrector Pili Muscle in Alopecia Areata but Not in Androgenetic Alopecia: A Model for Reversible Miniaturization and Potential for Hair Regrowth

22 citations , July 2012 in “International Journal of Trichology”

Miniaturized hairs stay connected to muscle in alopecia areata, allowing possible regrowth, but not in androgenetic alopecia.

research Abnormal Expression of VDR in the Hair Follicle of Alopecia Areata

January 2011 in “Guangdong Medical Journal”

Low Vitamin D receptor levels in hair follicles may contribute to alopecia areata.

research Alopecia

January 2002 in “Journal of the Korean Medical Association”

Recent research has provided important insights into hair growth and hair loss treatments.

research Comparison of Alopecia Areata in Human and Nonhuman Mammalian Species

71 citations , January 1998 in “Pathobiology”

The document concludes that certain rats and mice are useful for studying hair loss in humans and testing treatments.

Expression of Vascular Endothelial Growth Factor, Apoptosis Inhibitors (Survivin and p16) and CCL27 in Alopecia Areata Before and After Diphencyprone Treatment: An Immunohistochemical Study

Research cited in this study

research Alopecia Areata Update

research Hair Growth Effect of Minoxidil

research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

research Alopecia Areata Update

research Role of Cytotoxic T Cells in Chronic Alopecia Areata

research Expression of Vascular Endothelial Growth Factor (VEGF) in Various Compartments of the Human Hair Follicle

research Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells

research Loss of Vascular Endothelial Growth Factor in Human Alopecia Hair Follicles

research Immunohistochemical and Electron Microscopic Characterization of the Cellular Infiltrate in Alopecia Areata, Totalis, and Universalis

Related Community Posts Join

community The shedding caused by Minoxidil is one of the worst things. 2 months apart each picture

community Been on Fin 1 year and 7 months and 2.5 Oral minoxidil for 6 months

community Study: There is 70x Higher Unconjugated DHT in Feces Compared To Blood Levels in Young Adults - Gut Microbiota Manages DHT Recycling and Metabolism

community I started rapidly diffuse thinning at 22. I'm 42 now and have as much hair as I did at 16. AMA

community Alopecia Areata Question

community mbp alopecia areata or vitamin deficiency

Related Research

research Hair Follicle-Derived Mesenchymal Stem Cells Decrease Alopecia Areata Mouse Hair Loss and Reduce Inflammation Around the Hair Follicle

research Role of Vitamin D in Hair Loss: A Short Review

research The Role of Vitamin D in Non-Scarring Alopecia

research Hematological And Hepatic Effects Of Vascular Epidermal Growth Factor (VEGF) Used To Stimulate Hair Growth In An Animal Model

research Miniaturized Hairs Maintain Contact With the Arrector Pili Muscle in Alopecia Areata but Not in Androgenetic Alopecia: A Model for Reversible Miniaturization and Potential for Hair Regrowth

research Abnormal Expression of VDR in the Hair Follicle of Alopecia Areata

research Alopecia

research Comparison of Alopecia Areata in Human and Nonhuman Mammalian Species