Functional Regulation of Adipose-Derived Stem Cells by PDGF-D
October 2014
in “
Stem Cells
”
Studysummary This study found that PDGF-D acts as a potent mitogenic factor in adipose-derived stem cells, enhancing their proliferation, migration, and growth factor expression, suggesting its use as a preconditioning agent for ASC transplantation.
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The study investigated the role of platelet-derived growth factor-D (PDGF-D) in adipose-derived stem cells (ASCs), revealing that PDGF-D acted as a potent mitogenic factor, promoting ASC proliferation and migration through the PI3K/Akt pathways and mitochondrial reactive oxygen species (mtROS) generation. PDGF-D also upregulated various growth factors, enhancing the hair-regenerative potential of ASCs. The findings suggested that PDGF-D could serve as a novel stimulator and preconditioning agent for ASCs, potentially improving outcomes in ASC transplantation.
