Functional Regulation of Adipose-Derived Stem Cells by PDGF-D

    October 2014 in “ Stem Cells ”
    Ji Hye Kim, Sang Gyu Park, Wang-Kyun Kim, Sun U. Song, Jong-Hyuk Sung
    TLDR PDGF-D boosts stem cell growth and movement, enhancing hair regeneration.
    The study investigated the role of platelet-derived growth factor-D (PDGF-D) in adipose-derived stem cells (ASCs), revealing that PDGF-D acted as a potent mitogenic factor, promoting ASC proliferation and migration through the PI3K/Akt pathways and mitochondrial reactive oxygen species (mtROS) generation. PDGF-D also upregulated various growth factors, enhancing the hair-regenerative potential of ASCs. The findings suggested that PDGF-D could serve as a novel stimulator and preconditioning agent for ASCs, potentially improving outcomes in ASC transplantation.
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