TLDR Different types of fat tissue play important roles in metabolism, heat production, and healing.
The review highlights the morphofunctional properties of white, brown, and beige adipose tissues, emphasizing their roles in metabolic syndrome, thermogenesis, and physical adaptation. It underscores the need for specialized research on the morphofunctional changes of these tissues in repair processes. Notably, the study of adiponectins as growth factors reveals new insights into epithelial stem cell activity, hair growth cycle progression, wound healing, and hematopoiesis regulation. This research direction promises to enhance understanding of the pathophysiological mechanisms underlying metabolic syndrome.
106 citations
,
October 2016 in “Cell Stem Cell” PDGFA/AKT signaling is important for the growth and maintenance of certain skin fat cells.
130 citations
,
March 2014 in “Proceedings of the National Academy of Sciences of the United States of America” Epidermal Wnt/β-catenin signaling controls fat cell formation and hair growth.
829 citations
,
May 2007 in “Nature” Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.
7 citations
,
December 2021 in “Archives of Dermatological Research” Adiponectin reduces hair pigmentation and affects hair growth signals.
77 citations
,
March 2014 in “Cold Spring Harbor Perspectives in Medicine” Fat cells are important for healthy skin, hair growth, and healing, and changes in these cells can affect skin conditions and aging.
65 citations
,
January 2018 in “Nature Reviews Endocrinology” Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.
January 2019 in “Advances in stem cells and their niches” Skin health and repair depend on the signals between skin stem cells and their surrounding cells.
November 2023 in “International Journal of Medical Sciences” New regenerative medicine-based therapies for hair loss look promising but need more clinical validation.