Systematic Review of the Therapeutic Roles of Adipose Tissue in Dermatology

The systematic review analyzed the use of adipose tissue in dermatology for scar treatment, wound healing, and hair growth across 13 studies. It found that most studies reported positive outcomes with adipose tissue treatments, with evidence suggesting that adipose-derived stem cells (ASCs) may promote wound healing and hair growth. However, the review highlighted the low level of evidence due to small sample sizes and the absence of control groups in many studies. For instance, studies by Piccolo et al. (282 patients), Shin et al. (27 patients), and Perez-Meza et al. (9 patients) showed promising results but lacked rigorous controls. The review concluded that while adipose tissue treatments show potential, there is a need for larger, well-controlled randomized clinical trials to confirm their efficacy in dermatology for scars, wound healing, and hair growth. Concerns about the relationship between adipose-derived treatments and cancer risk were also noted, emphasizing the need for further research to clarify benefits and risks.