Adipose-Derived Stem Cells in Skin Diseases, Wound Healing, and Skin Defects: A Review

September 2022 in “ Cytotherapy ”

Isabelle Schneider, Maurizio Calcagni, Johanna Buschmann

adipose-derived stem cells ASCs wound healing chronic wounds diabetic ulcers burn wounds alopecia atopic dermatitis immunomodulatory pro-angiogenic scar formation neovascularization growth factors stem cells hair loss eczema immune-modulating new blood vessels scar reduction

TLDR Fat-derived stem cells show promise for treating skin issues and improving wound healing, but more research is needed to confirm the best way to use them.

The review discusses the potential of adipose-derived stem cells (ASCs) in treating skin diseases, wound healing, and skin defects. ASCs have been found to promote wound healing, particularly in chronic wounds or diabetic patients, due to their immunomodulatory and pro-angiogenic characteristics. They can also reduce scar formation and mediate neovascularization. ASCs have been used in treating diabetic ulcers, burn wounds, alopecia, and atopic dermatitis. In terms of hair loss, ASCs secrete growth factors that activate neighboring cells, making them a potential therapeutic option. However, the review highlights the need for larger standardized studies to establish optimal treatment. The review also notes that while ASCs have shown potential in diabetic wound healing, the effectiveness of autologous administration in diabetic patients seems to be impacted and should be carefully evaluated.

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research Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men

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