Adipose-Derived Stem Cells in Skin Diseases, Wound Healing, and Skin Defects: A Review

February 2023 in “ Cytotherapy ”

Isabelle Schneider, Maurizio Calcagni, Johanna Buschmann

adipose-derived stem cells ASCs wound healing chronic wounds diabetic ulcers burn wounds alopecia atopic dermatitis immunomodulatory pro-angiogenic scar formation neovascularization growth factors stem cells hair loss eczema immune-modulating new blood vessels scar reduction

TLDR Fat-derived stem cells show promise for treating skin issues and improving wound healing, but more research is needed to confirm the best way to use them.

The review discusses the potential of adipose-derived stem cells (ASCs) in treating skin diseases, wound healing, and skin defects. ASCs have been found to promote wound healing, particularly in chronic wounds or diabetic patients, due to their immunomodulatory and pro-angiogenic characteristics. They can also reduce scar formation and mediate neovascularization. ASCs have been used in treating diabetic ulcers, burn wounds, alopecia, and atopic dermatitis. In terms of hair loss, ASCs secrete growth factors that activate neighboring cells, making them a potential therapeutic option. However, the review highlights the need for larger standardized studies to establish optimal treatment. The review also notes that while ASCs have shown potential in diabetic wound healing, the effectiveness of autologous administration in diabetic patients seems to be impacted and should be carefully evaluated.

View this study on isct-cytotherapy.org →

Discuss this study in the Community →

Cited in this study

25 / 25 results

research Effects of Adipose-Derived Stem Cells and Platelet-Rich Plasma for Prevention of Alopecia and Other Skin Complications of Radiotherapy

6 citations , May 2021 in “Annals of Plastic Surgery”

research AIRMESS – Academy of International Regenerative Medicine & Surgery Societies: Recommendations in the Use of Platelet-Rich Plasma (PRP) and Autologous Stem Cell-Based Therapy (ASC-BT) in Androgenetic Alopecia and Wound Healing

17 citations , April 2021 in “Expert Opinion on Biological Therapy”

Use PRP and ASC-BT for hair loss and wound healing, but more research needed.

research Systematic Review: Adipose-Derived Mesenchymal Stem Cells, Platelet-Rich Plasma, and Biomaterials as New Regenerative Strategies in Chronic Skin Wounds and Soft Tissue Defects

70 citations , February 2021 in “International Journal of Molecular Sciences”

Fat-derived stem cells, platelet-rich plasma, and biomaterials show promise for healing chronic skin wounds and improving soft tissue with few side effects.

research The Effect of Conditioned Media From Human Adipocyte-Derived Mesenchymal Stem Cells on Androgenetic Alopecia After Nonablative Fractional Laser Treatment

10 citations , December 2020 in “Dermatologic Surgery”

research Promotion of Hair Growth by Conditioned Medium from Extracellular Matrix/Stromal Vascular Fraction Gel in C57BL/6 Mice

13 citations , June 2020 in “Stem Cells International”

A substance from a specific gel helped to grow hair effectively in mice, suggesting it could potentially be used to treat hair loss in humans.

research Sequential Scalp Assessment in Hair Regeneration Therapy Using an Adipose-Derived Stem Cell-Conditioned Medium

33 citations , June 2020 in “Dermatologic Surgery”

Using a special stem cell formula on the scalp once a month for six months helped people with hair loss grow more hair.

research A Review of the Treatment of Male Pattern Hair Loss

53 citations , February 2020 in “Expert Opinion on Pharmacotherapy”

Finasteride and minoxidil work best together for hair loss.

research Autologous Micrografts from Scalp Tissue: Trichoscopic and Long-Term Clinical Evaluation in Male and Female Androgenetic Alopecia

41 citations , January 2020 in “BioMed Research International”

Micrografts improve hair density and thickness without side effects.

research Impact of Different Preparation Methods to Obtain Autologous Non-Activated Platelet-Rich Plasma and Activated Platelet-Rich Plasma in Plastic Surgery: Wound Healing and Hair Regrowth Evaluation

58 citations , January 2020 in “International Journal of Molecular Sciences”

Different methods of preparing Platelet-Rich Plasma (PRP) can affect wound healing and hair regrowth in plastic surgery. Using a kit with specific standards helps isolate PRP that meets quality criteria. Non-Activated PRP and Activated PRP have varying effects depending on the tissue and condition treated. For hair regrowth, Non-Activated PRP increased hair density more than Activated PRP. Both treatments improved various aspects of scalp health.

research Autologous Cellular Method Using Micrografts of Human Adipose Tissue Derived Follicle Stem Cells in Androgenic Alopecia

88 citations , July 2019 in “International Journal of Molecular Sciences”

Using human fat tissue derived stem cells in micrografts can safely and effectively increase hair density in people with hair loss.

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

136 citations , May 2019 in “Cells”

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

research Mesenchymal Stem Cells and Stromal Vascular Fraction for Hair Loss

13 citations , November 2018 in “Facial Plastic Surgery Clinics of North America”

Adipose tissue shows promise for hair regrowth, but more research is needed to confirm best practices and effectiveness.

research Introducing Platelet-Rich Stroma: Platelet-Rich Plasma and Stromal Vascular Fraction Combined for the Treatment of Androgenetic Alopecia

40 citations , July 2018 in “Aesthetic Surgery Journal”

New treatment combining PRP and SVF increases hair density in 6-12 weeks for androgenetic alopecia patients.

research Cellular Therapy with Human Autologous Adipose-Derived Adult Cells of Stromal Vascular Fraction for Alopecia Areata

45 citations , May 2018 in “Stem Cell Research & Therapy”

Using patients' own fat-derived cells to treat alopecia areata significantly improved hair growth and was safe.

research Up-To-Date Clinical Trials of Hair Regeneration Using Conditioned Media of Adipose-Derived Stem Cells in Male and Female Pattern Hair Loss

30 citations , September 2017 in “Current stem cell research & therapy”

Adipose-derived stem cells (fat cells) show promise in treating hair loss in both men and women.

research Hair Regeneration Therapy: Application of Adipose-Derived Stem Cells

55 citations , September 2017 in “Current stem cell research & therapy”

Using fat-derived stem cells for hair loss treatment is safe and effective, improving hair growth and patient satisfaction.

research Stem Cells from Human Hair Follicles: First Mechanical Isolation for Immediate Autologous Clinical Use in Androgenetic Alopecia and Hair Loss

86 citations , June 2017 in “Stem cell investigation”

Stem cells from hair follicles can safely treat hair loss.

research Clinical Use of Conditioned Media of Adipose Tissue-Derived Stem Cells in Female Pattern Hair Loss: A Retrospective Case Series Study

83 citations , June 2015 in “International Journal of Dermatology”

ADSC-CM treatment improved hair density and thickness in women with hair loss, safely and effectively.

research Adipose Derived Stem Cells and Growth Factors Applied in Hair Transplantation: Follow-Up of Clinical Outcome

20 citations , January 2014 in “Journal of Cosmetics, Dermatological Sciences and Applications”

Using adipose derived stem cells and growth factors in hair transplants may improve healing and hair growth.

research Ultraviolet B Preconditioning Enhances the Hair Growth-Promoting Effects of Adipose-Derived Stem Cells Via Generation of Reactive Oxygen Species

41 citations , January 2013 in “Stem Cells and Development”

Low-dose UVB light improves hair growth effects of certain stem cells by increasing reactive oxygen species.

research Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men

198 citations , October 2011 in “Journal der Deutschen Dermatologischen Gesellschaft”

Use minoxidil for hair loss; finasteride and dutasteride for men, dutasteride for women.

research Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling

499 citations , September 2011 in “Cell”

Fat-related cells are important for initiating hair growth.

research Hair Growth Promoting Effects of Adipose Tissue-Derived Stem Cells

81 citations , February 2010 in “Journal of Dermatological Science”

Fat tissue stem cells may help increase hair growth.

research Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion

134 citations , January 2010 in “Biomedical research”

Low oxygen conditions increase the hair-growing effects of substances from fat-derived stem cells by boosting growth factor release.

research Prevalence of Male Pattern Hair Loss in 18–49 Year Old Men

50 citations , December 1998 in “Dermatologic Surgery”

Hair loss is more common in men aged 18-49 and increases with age.

2 / 2 results

research Stem Cells in Skin Regeneration, Wound Healing, and Their Clinical Applications

232 citations , October 2015 in “International journal of molecular sciences”

Stem cells are crucial for skin repair and new treatments for chronic wounds.

research Exploring the Role of Stem Cells in Cutaneous Wound Healing

222 citations , November 2009 in “Experimental Dermatology”

Stem cells are crucial for wound healing and understanding their role could lead to new treatments, but more research is needed to answer unresolved questions.