Hair Regeneration Therapy: Application of Adipose-Derived Stem Cells

September 2017 in “ Current stem cell research & therapy ”

Hirotaro Fukuoka, Keigo Narita, Hirotaka Suga

adipose-derived stem cell-conditioned medium ADSC-CM AAPE alopecia intradermal injections vitamins amino acids hair regeneration hair growth

TLDR Using fat-derived stem cells for hair loss treatment is safe and effective, improving hair growth and patient satisfaction.

The document described the use of adipose-derived stem cell-conditioned medium (ADSC-CM), specifically a commercialized formulation called AAPEⓇ, for treating alopecia. The treatment, which was administered via intradermal injections along with vitamins and amino acids, was applied in 170 facilities in Japan. Significant hair growth was observed after 2-3 months, with increased patient satisfaction correlating with the number of treatments. A test involving 10 patients showed a significant increase in hair count on the treated side compared to the placebo side. Over 1,000 patients were treated without serious complications, indicating that ADSC-CM is a highly effective and safe treatment for hair regeneration with minimal side effects.

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Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men

research Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion

134 citations, January 2010 in “Biomedical research”

Low oxygen conditions increase the hair-growing effects of substances from fat-derived stem cells by boosting growth factor release.

research Alopecia Secondary to Mesotherapy

49 citations, October 2009 in “Journal of the American Academy of Dermatology”

Some people experienced hair loss after mesotherapy treatments for hair loss.

research Multifocal Scalp Abscess With Subcutaneous Fat Necrosis And Scarring Alopecia As A Complication Of Scalp Mesotherapy

8 citations, January 2008 in “PubMed”

Mesotherapy for the scalp can cause severe infections, fat tissue death, and permanent hair loss.

research Chemoprevention of Smoke-Induced Alopecia in Mice by Oral Administration of L-Cystine and Vitamin B6

41 citations, June 2007 in “Journal of dermatological science”

Taking L-cystine and vitamin B6 can prevent hair loss caused by smoke in mice.

Hair Regeneration Therapy: Application of Adipose-Derived Stem Cells

Cited in this study

research Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men

research Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling

research Efficacy and Safety of Finasteride Therapy for Androgenetic Alopecia

research Hair Growth Promoting Effects of Adipose Tissue-Derived Stem Cells

research Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion

research Alopecia Secondary to Mesotherapy

research Multifocal Scalp Abscess With Subcutaneous Fat Necrosis And Scarring Alopecia As A Complication Of Scalp Mesotherapy

research Chemoprevention of Smoke-Induced Alopecia in Mice by Oral Administration of L-Cystine and Vitamin B6