Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion

    January 2010 in “ Biomedical research ”
    Byung-Soon Park, Won‐Serk Kim, Joon-Seok Choi, Hyung-Ki Kim, Jong-Hyun Won, Fumio Ohkubo, Hirotaro Fukuoka
    Image of study
    TLDR Low oxygen conditions increase the hair-growing effects of substances from fat-derived stem cells by boosting growth factor release.
    In the 2010 study by Park et al., it was discovered that conditioned medium (CM) from adipose-derived stem cells (ADSCs) significantly promoted hair growth by inducing the anagen phase and increasing hair regeneration in C3H/NeH mice, with 21 mice used in the experiment. The CM also enhanced the proliferation of human follicle dermal papilla cells (HFDPCs) and human epithelial keratinocytes (HEKs). Importantly, the study revealed that hypoxic conditions further amplified the hair growth effects by increasing the secretion of growth factors such as IGFBP-1, IGFBP-2, M-CSF, M-CSF receptor, PDGF receptor-ß, and VEGF, while decreasing EGF secretion. This suggests that the paracrine effects of ADSCs on hair growth are more potent under hypoxia due to the elevated release of specific growth factors.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 1000+ results

      community 21 months in, lost all gains last 2 weeks

      in Progress Pictures  446 upvotes 5 months ago
      The user experienced hair loss after 21 months of using oral minoxidil and finasteride and is considering switching to dutasteride. Others suggest it might be temporary and recommend staying consistent or trying additional methods like hair loss shampoo, microneedling, or checking vitamin levels.

      community One year results on Big 3 + Dermaroll (32y/o NW7)

      in Treatment  218 upvotes 6 years ago
      A user who experienced significant hair regrowth over the course of one year by following a regimen including finasteride, minoxidil, Nizoral shampoo, dermarolling, biotin vitamins, vitamin D3 and collagen peptides. The post includes before/after photos and details on the brands used.

      community 2000 beard graft extracted with no visible scar

      in Progress Pictures  213 upvotes 3 weeks ago
      A user shared their experience with a beard-to-scalp hair transplant, noting no visible scars and improved hair density using finasteride and minoxidil. The conversation discusses the differences between beard and scalp hair, potential changes in hair texture, and the use of beard hair for increased scalp coverage.

    Related Research

    6 / 6 results