TLDR Low oxygen conditions increase the hair-growing effects of substances from fat-derived stem cells by boosting growth factor release.
In the 2010 study by Park et al., it was discovered that conditioned medium (CM) from adipose-derived stem cells (ADSCs) significantly promoted hair growth by inducing the anagen phase and increasing hair regeneration in C3H/NeH mice, with 21 mice used in the experiment. The CM also enhanced the proliferation of human follicle dermal papilla cells (HFDPCs) and human epithelial keratinocytes (HEKs). Importantly, the study revealed that hypoxic conditions further amplified the hair growth effects by increasing the secretion of growth factors such as IGFBP-1, IGFBP-2, M-CSF, M-CSF receptor, PDGF receptor-ß, and VEGF, while decreasing EGF secretion. This suggests that the paracrine effects of ADSCs on hair growth are more potent under hypoxia due to the elevated release of specific growth factors.
81 citations
,
December 2009 in “Journal of Dermatological Science” Fat tissue stem cells may help increase hair growth.
136 citations
,
June 2006 in “Journal of Dermatological Science” PDGF isoforms can promote and sustain hair growth.
224 citations
,
March 2006 in “Seminars in Cutaneous Medicine and Surgery” The document concludes that understanding hair follicle biology can lead to better hair loss treatments.
277 citations
,
June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.
520 citations
,
February 2001 in “Journal of Clinical Investigation” VEGF helps hair grow and determines follicle size by increasing blood vessel growth.
109 citations
,
April 1998 in “Journal of Investigative Dermatology”
January 2022 in “Journal of St. Marianna University” Substances from human hair cells can affect hair loss-related genes, potentially leading to new treatments for baldness.
15 citations
,
April 2014 in “Experimental Dermatology” Scientists developed a system to study human hair growth using skin cells, which could help understand hair development and improve skin substitutes for medical use.
321 citations
,
December 2009 in “Journal of Dermatological Science” Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.
32 citations
,
August 2006 in “Archives of Dermatological Research” Dermal papilla cells can help regrow hair follicles.
January 2003 in “Chinese Journal of Reparative and Reconstructive Surgery” Dermal papilla cells can help form hair follicles and produce hair.
66 citations
,
August 2001 in “Experimental Dermatology” Human hair follicle cells can grow hair when put into mouse skin if they stay in contact with mouse cells.
57 citations
,
November 1998 in “Wound Repair and Regeneration” Hair papilla cells can create and regenerate hair bulbs under the right conditions.
