Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion

    January 2010 in “ Biomedical research
    Byung-Soon Park, Won‐Serk Kim, Joon-Seok Choi, Hyung-Ki Kim, Jong-Hyun Won, Fumio Ohkubo, Hirotaro Fukuoka
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    TLDR Low oxygen conditions increase the hair-growing effects of substances from fat-derived stem cells by boosting growth factor release.
    In the 2010 study by Park et al., it was discovered that conditioned medium (CM) from adipose-derived stem cells (ADSCs) significantly promoted hair growth by inducing the anagen phase and increasing hair regeneration in C3H/NeH mice, with 21 mice used in the experiment. The CM also enhanced the proliferation of human follicle dermal papilla cells (HFDPCs) and human epithelial keratinocytes (HEKs). Importantly, the study revealed that hypoxic conditions further amplified the hair growth effects by increasing the secretion of growth factors such as IGFBP-1, IGFBP-2, M-CSF, M-CSF receptor, PDGF receptor-ß, and VEGF, while decreasing EGF secretion. This suggests that the paracrine effects of ADSCs on hair growth are more potent under hypoxia due to the elevated release of specific growth factors.
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