Advanced Medical Treatments for Hair Loss

    October 2025 in “ Cell Transplantation ”
    Kwanrudee Kaewmungkun, Somruethai Kaisang, Nattida Yokhaphachon, Rangsun Parnpai
    Studysummary This review discusses recent advancements in hair loss treatments, including stem cell and hair follicle cell therapies, growth factors, extracellular vesicles, gene therapy, and tissue engineering, highlighting their potential in improving hair regeneration and follicle health.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 67

    1. Proteins from Stressed Mesenchymal Stem Cells Can Repair Hair Follicles and Promote Hair Regeneration ACS Pharmacology & Translational Science · 2025
    2. Recent Advances in Drug Development for Hair Loss International Journal of Molecular Sciences · 2025
    3. Bulge-Derived Epithelial Cells Isolated From Human Hair Follicles Using Enzymatic Digestion Or Explants Result In Comparable Tissue-Engineered Skin International Journal of Molecular Sciences · 2025
    4. Mesenchymal Stem Cell Exosome Therapy for Acquired Trichorrhexis Nodosa: A Case Series Journal of Cosmetic Dermatology · 2024
    5. Crosstalk Between Endothelial Cells and Dermal Papilla Entails Hair Regeneration and Angiogenesis During Aging Journal of Advanced Research · 2024
    6. Autologous Stem Cell-Derived Therapies for Androgenetic Alopecia: A Systematic Review of Randomized Control Trials on Efficacy, Safety, and Outcomes Plastic and Reconstructive Surgery – Global Open · 2024
    7. CRISPR/Cas9: A Promising Approach for Alopecia Biomedical journal of scientific & technical research · 2024
    8. Hair Follicle Development of Rex Rabbits Is Regulated Seasonally by Wnt10b/β-Catenin, TGFβ-BMP, IGF1, and EGF Signaling Pathways Animals · 2023
    9. High Migratory Activity of Dermal Sheath Cup Cells and Clinical Efficacy in Autologous Therapy for Hair Loss Journal of Dermatological Science · 2023
    10. Efficacy of Autologous Dermal Sheath Cup Cell Transplantation in Male and Female Pattern Hair Loss: A Single-Arm, Multi-Center, Phase III Equivalent Clinical Study The Journal of Dermatology · 2023
    11. Potential Natural Products Regulation of Molecular Signaling Pathway in Dermal Papilla Stem Cells Molecules · 2023
    12. Systematic Review of Exosome Treatment in Hair Restoration: Preliminary Evidence, Safety, and Future Directions Journal of Cosmetic Dermatology · 2023
    13. A Clinical Trial of Treating Androgenic Alopecia with Mesenchymal Stem Cell Suspension Derived from Autologous Hair Follicle Plastic and Reconstructive Surgery · 2023
    14. Investigation of Exacerbating Factors for Postpartum Hair Loss: A Questionnaire-Based Cross-Sectional Study International Journal of Women’s Dermatology · 2023
    15. Treatment of Persistent Chemotherapy-Induced Hair Loss (Alopecia) With Human Mesenchymal Stromal Cells Exosome Enriched Extracellular Vesicles: A Case Report Heliyon · 2023
    16. Duo-Role Platelet-Rich Plasma: Temperature-Induced Fibrin Gel and Growth Factors' Reservoir for Microneedles to Promote Hair Regrowth Journal of Advanced Research · 2023
    17. Dermal Papilla Cell-Derived Exosomes Regulate Hair Follicle Stem Cell Proliferation via LEF1 International Journal of Molecular Sciences · 2023
    18. Expansion Culture of Hair Follicle Stem Cells Through Uniform Aggregation in Microwell Array Devices ACS Biomaterials Science & Engineering · 2023
    19. Extracellular Vesicles From 3D Cultured Dermal Papilla Cells Improve Wound Healing Via Krüppel-Like Factor 4/Vascular Endothelial Growth Factor A-Driven Angiogenesis Burns and trauma · 2023
    20. The Molecular Mechanism of Natural Products Activating Wnt/Beta-Catenin Signaling Pathway for Improving Hair Loss Life · 2022
    21. Effective And Economical Cell Therapy For Hair Regeneration Biomedicine & Pharmacotherapy · 2022
    22. A Comprehensive Review of Platelet-Rich Plasma for the Treatment of Dermatologic Disorders Journal of Dermatological Treatment · 2022
    23. A Survey of Patient Attitudes Towards Topical Minoxidil in the Treatment of Hair Loss PubMed · 2022
    24. A Drug-Free, Hair Follicle Cycling Regulatable, Separable, Antibacterial Microneedle Patch for Hair Regeneration Therapy Advanced healthcare materials/Advanced Healthcare Materials · 2022
    25. 3D Spheroid Human Dermal Papilla Cell as an Effective Model for the Screening of Hair Growth Promoting Compounds: Examples of Minoxidil and 3,4,5-Tri-O-Caffeoylquinic Acid (TCQA) Cells · 2022
    26. Advancing Regenerative Cellular Therapies in Non-Scarring Alopecia Pharmaceutics · 2022
    27. Exosomes Secreted from Adipose-Derived Stem Cells Are a Potential Treatment Agent for Immune-Mediated Alopecia Journal of immunology research · 2022
    28. Exosomes Derived From Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation Through The Wnt3a/Beta-Catenin Signaling Pathway Oxidative Medicine and Cellular Longevity · 2022
    29. Innovative Method of Alopecia Treatment by Autologous Adipose-Derived SVF Stem Cell Research & Therapy · 2021
    30. TGF-β2 and Collagen Play Pivotal Roles in the Spheroid Formation and Anti-Aging of Human Dermal Papilla Cells Aging · 2021
    31. A Systematic Summary of Survival and Death Signaling During the Life of Hair Follicle Stem Cells Stem Cell Research & Therapy · 2021
    32. Hair Transplantation: Basic Overview Journal of The American Academy of Dermatology · 2021
    33. Wharton's Jelly-Derived Mesenchymal Stem Cells in the Treatment of Four Patients with Alopecia Areata Advances in Clinical and Experimental Medicine · 2021
    34. Oral Minoxidil Treatment for Hair Loss: A Review of Efficacy and Safety Journal of The American Academy of Dermatology · 2020
    35. Asian Hair: A Review of Structures, Properties, and Distinctive Disorders Clinical, Cosmetic and Investigational Dermatology · 2020
    36. The Efficacy and Safety of Finasteride Combined with Topical Minoxidil for Androgenetic Alopecia: A Systematic Review and Meta-Analysis Aesthetic Plastic Surgery · 2020
    37. CRISPR/Cas9-Mediated Disruption of Fibroblast Growth Factor 5 in Rabbits Results in a Systemic Long Hair Phenotype by Prolonging Anagen Genes · 2020
    38. Autologous Cell-Based Therapy for Male and Female Pattern Hair Loss Using Dermal Sheath Cup Cells: A Randomized Placebo-Controlled Double-Blinded Dose-Finding Clinical Study Journal of The American Academy of Dermatology · 2020
    39. Finasteride and Its Potential for the Treatment of Female Pattern Hair Loss: Evidence to Date Drug Design Development and Therapy · 2020
    40. Autologous Micrografts from Scalp Tissue: Trichoscopic and Long-Term Clinical Evaluation in Male and Female Androgenetic Alopecia BioMed Research International · 2020
    41. Ultrasound-Activated Particles as CRISPR/Cas9 Delivery System for Androgenic Alopecia Therapy Biomaterials · 2019
    42. Minoxidil and Its Use in Hair Disorders: A Review DOAJ (DOAJ: Directory of Open Access Journals) · 2019
    43. Follicular Unit Extraction (FUE) Hair Transplant: Curves Ahead Journal of Maxillofacial and Oral Surgery · 2019
    44. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019
    45. Finasteride and Androgenic Alopecia: From Therapeutic Options to Medical Implications Journal of Dermatological Treatment · 2019
    46. Characterization of Human Dermal Papilla Cells in Alginate Spheres Applied sciences · 2018
    47. Hair Biology Facial Plastic Surgery Clinics of North America · 2018
    48. Dissociated Skin Cells Regenerate Hair Follicles in a Microwound: The Punch Assay Experimental Dermatology · 2018
    49. Cellular Therapy with Human Autologous Adipose-Derived Adult Cells of Stromal Vascular Fraction for Alopecia Areata Stem Cell Research & Therapy · 2018
    50. Extracellular Vesicles Derived from MSCs Activate Dermal Papilla Cells In Vitro and Promote Hair Follicle Conversion from Telogen to Anagen in Mice Scientific Reports · 2017
    51. Hair Transplantation Controversies Dermatologic Surgery · 2017
    52. Hair Follicle Growth by Stromal Vascular Fraction-Enhanced Adipose Transplantation in Baldness Stem cells and cloning · 2017
    53. Anatomy and Physiology of Hair InTech eBooks · 2017
    54. Stem Cell Therapy as a Novel Therapeutic Intervention for Resistant Cases of Alopecia Areata and Androgenetic Alopecia Journal of Dermatological Treatment · 2016
    55. Activating Beta-Catenin Signaling in CD133-Positive Dermal Papilla Cells Increases Hair Inductivity FEBS Journal · 2016
    56. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    57. The Changes in the Hair Cycle During Gestation and the Post-Partum Period Journal of the European Academy of Dermatology and Venereology · 2013
    58. Dermal Papilla Cells Serially Cultured with Wnt-10b Sustain Their Hair Follicle Induction Activity After Transplantation into Nude Mice Cell Transplantation · 2012
    59. Clonal Growth of Dermal Papilla Cells in Hydrogels Reveals Intrinsic Differences Between Sox2-Positive and Sox2-Negative Cells In Vitro and In Vivo Journal of Investigative Dermatology · 2011
    60. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
    61. Finasteride Treatment of Hair Loss in Women Annals of Pharmacotherapy · 2010
    62. The Mesenchymal Component of Hair Follicle Neogenesis: Background, Methods, and Molecular Characterization Experimental Dermatology · 2009
    63. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    64. Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle Journal of Dermatological Science · 2004
    65. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    66. Role of Hair Papilla Cells in Induction and Regeneration Processes of Hair Follicles Wound Repair and Regeneration · 1998
    67. Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography Journal of Investigative Dermatology · 1984

    Related research 8

    1. Comparative Study of Topical Minoxidil (5%) Plus Finasteride (0.1%) Versus Platelet-Rich Plasma Plus Topical Minoxidil (5%) Plus Finasteride (0.1%) in Patients with Androgenic Alopecia Asian Journal of Pharmaceutical and Clinical Research · 2024
    2. A Randomized, Double-Blind Controlled Study of the Efficacy and Safety of Topical Solution of 0.25% Finasteride Admixed with 3% Minoxidil vs. 3% Minoxidil Solution in the Treatment of Male Androgenetic Alopecia Journal of The European Academy of Dermatology and Venereology · 2018
    3. Topical Minoxidil for the Treatment of Alopecia Areata PubMed · 2017
    4. The Modern Treatment of Androgenetic Alopecia Vestnik dermatologii i venerologii · 2017
    5. Topical Minoxidil Fortified with Finasteride: Maintenance of Hair Density After Replacing Oral Finasteride International journal of scientific research · 2016
    6. Combined Treatment with Oral Finasteride and Topical Minoxidil in Male Androgenetic Alopecia: A Randomized and Comparative Study in Chinese Patients Dermatologic Therapy · 2015
    7. A New Topical Formulation of Minoxidil and Finasteride Improves Hair Growth in Men with Androgenetic Alopecia Journal of clinical & experimental dermatology research · 2015
    8. Effectivity of Minoxidil as a Treatment for Alopecia Areata DOAJ (DOAJ: Directory of Open Access Journals) · 2013