Duo-Role Platelet-Rich Plasma: Temperature-Induced Fibrin Gel and Growth Factors' Reservoir for Microneedles to Promote Hair Regrowth

February 2023 in “ Journal of Advanced Research ”

Yang Sun, Lunan Yang, Lijuan Du, Yi Zhou, Kaige Xu, Jian Chen, Ye He, Qian Qu, Yong Miao, Malcolm Xing, Zhiqi Hu

platelet-rich plasma PRP fibrin gel microneedles MN gelatin methacryloyl GelMA growth factors GFs VEGF PDGF TGF-β hair follicles hair regrowth in vivo experiments

TLDR A new method using Platelet-rich Plasma (PRP) in a microneedle can promote hair regrowth more efficiently and is painless, minimally invasive, and affordable.

The study introduces a new method for promoting hair regrowth using temperature-sensitive Platelet-rich Plasma (PRP) induced fibrin gel incorporated in a detachable transdermal microneedle (MN). The PRP gel, combined with gelatin methacryloyl (GelMA), allows for sustained release of growth factors (GFs) such as VEGF, PDGF, and TGF-β around the hair follicles for 4-6 days, promoting hair regrowth in mice models. The PRP-MNs were found to be convenient, minimally invasive, painless, inexpensive to manufacture, storable, and effective in boosting hair regeneration. In vivo experiments showed that PRP-MNs induced hair regrowth more efficiently than other methods, with 77% hair regrowth after 15 days compared to 52.3% in the PRP group. The study concluded that PRP-MNs provide a painless, minimally invasive, and sustainable effect of PRP for hair regrowth.

View this study on sciencedirect.com →

Discuss this study in the Community →

Cited in this study

36 / 36 results

research The Glypican-1/HGF/C-Met and Glypican-1/VEGF/VEGFR2 Ternary Complexes Regulate Hair Follicle Angiogenesis

10 citations , December 2021 in “Frontiers in cell and developmental biology”

Glypican-1 is important for blood vessel growth in hair follicles and could help treat hair loss.

research Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment

38 citations , July 2021 in “ACS Nano”

Microneedles help treat hair loss by improving hair surroundings and promoting growth.

research Bacteria Induce Skin Regeneration via IL-1β Signaling

53 citations , May 2021 in “Cell Host & Microbe”

Skin bacteria, specifically Staphylococcus aureus, help in wound healing and hair growth by using IL-1β signaling. Using antibiotics on skin wounds can slow down this natural healing process.

research Complications with Hair Transplantation

12 citations , May 2020 in “Facial Plastic Surgery Clinics of North America”

Hair transplant complications are rare with good planning and technique, but risks include infection, bleeding, and patient dissatisfaction.

research The Efficacy and Safety of Finasteride Combined with Topical Minoxidil for Androgenetic Alopecia: A Systematic Review and Meta-Analysis

8 citations , March 2020 in “Aesthetic Plastic Surgery”

Finasteride and minoxidil together safely and effectively increase hair growth and density for androgenetic alopecia.

research Autologous Activated Platelet-Rich Plasma (AA-PRP) and Non-Activated (A-PRP) in Hair Growth: A Retrospective, Blinded, Randomized Evaluation in Androgenetic Alopecia

44 citations , February 2020 in “Expert Opinion on Biological Therapy”

research Impact of Different Preparation Methods to Obtain Autologous Non-Activated Platelet-Rich Plasma and Activated Platelet-Rich Plasma in Plastic Surgery: Wound Healing and Hair Regrowth Evaluation

58 citations , January 2020 in “International Journal of Molecular Sciences”

Different methods of preparing Platelet-Rich Plasma (PRP) can affect wound healing and hair regrowth in plastic surgery. Using a kit with specific standards helps isolate PRP that meets quality criteria. Non-Activated PRP and Activated PRP have varying effects depending on the tissue and condition treated. For hair regrowth, Non-Activated PRP increased hair density more than Activated PRP. Both treatments improved various aspects of scalp health.

research Transdermal Finasteride Delivery via Powder-Carrying Microneedles with a Diffusion Enhancer to Treat Androgenetic Alopecia

33 citations , December 2019 in “Journal of Controlled Release”

Microneedles with enhancer effectively promote hair growth and increase hair density.

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

136 citations , May 2019 in “Cells”

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

research A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth

192 citations , April 2019 in “ACS nano”

A new microneedle patch made from hair proteins helps regrow hair faster and better than current treatments.

research Is Skin Microneedling a Good Alternative Method for Various Skin Defects Removal

23 citations , September 2018 in “Dermatologic Therapy”

Microneedling is a safe and effective way to improve various skin conditions with minimal side effects.

research Guidelines for the Diagnosis and Treatment of Male-Pattern and Female-Pattern Hair Loss, 2017 Version

36 citations , June 2018 in “Journal of Dermatology”

Use finasteride, dutasteride, and minoxidil for hair loss treatment.

research Transcutaneous Implantation of Valproic Acid-Encapsulated Dissolving Microneedles Induces Hair Regrowth

68 citations , June 2018 in “Biomaterials”

Tiny needles with valproic acid can effectively regrow hair.

research Evidence-Based Guideline for the Treatment of Androgenetic Alopecia in Women and Men – Short Version

145 citations , January 2018 in “Journal of The European Academy of Dermatology and Venereology”

Use minoxidil for hair loss treatment; assess results after 6 months.

research Hair Transplantation Controversies

31 citations , November 2017 in “Dermatologic Surgery”

Hair transplants look natural, but the best method is debated, and PRP shows promise for hair regrowth.

research Platelet-Rich Plasma Stimulates Angiogenesis in Mice Which May Promote Hair Growth

14 citations , October 2017 in “European Journal of Medical Research”

Platelet-rich plasma can help grow more and longer hair by creating new blood vessels.

research Platelet-Rich Plasma for the Aesthetic Surgeon

27 citations , July 2017 in “Facial Plastic Surgery”

Platelet-Rich Plasma (PRP) shows promise for hair growth and skin improvement in aesthetic surgery.

research Platelet-Rich Plasma for the Treatment of Female Pattern Hair Loss: A Patient Survey

5 citations , April 2017 in “Dermatologic Surgery”

PRP treatment satisfies 58% of female hair loss patients, with most noticing fuller, thicker hair and less shedding.

research Evaluation of Non-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems

136 citations , February 2017 in “International Journal of Molecular Sciences”

PRP treatment improves hair growth, and the device used can affect results, with some being more effective.

research Meta-Analysis of Efficacy of Platelet-Rich Plasma Therapy for Androgenetic Alopecia

57 citations , January 2017 in “Journal of Dermatological Treatment”

PRP therapy may effectively treat hair loss, but more research needed.

research Differential Expression Between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia

46 citations , August 2016 in “Journal of Investigative Dermatology”

New genes found linked to balding, may help develop future treatments.

research A Guide to Studying Human Hair Follicle Cycling In Vivo

212 citations , January 2016 in “Journal of Investigative Dermatology”

The document provides a method to classify human hair growth stages using a model with human scalp on mice, aiming to standardize hair research.

research Applications of Platelet-Rich Plasma in Dermatology: A Critical Appraisal of the Literature

79 citations , October 2015 in “Journal of Dermatological Treatment”

Platelet-rich plasma may have some benefits in dermatology, but there's not enough evidence to widely recommend its use.

research The Effect of Platelet-Rich Plasma in Hair Regrowth: A Randomized Placebo-Controlled Trial

214 citations , September 2015 in “Stem Cells Translational Medicine”

Platelet-rich plasma injections significantly improved hair regrowth and thickness in patients with hair loss.

research A Review of Medical and Surgical Treatment Options for Androgenetic Alopecia

41 citations , December 2014 in “JAMA Facial Plastic Surgery”

Use finasteride, minoxidil, and follicular unit transplantation for hair loss treatment.

research Study of Platelet-Rich Plasma Injections in the Treatment of Androgenetic Alopecia Through a One-Year Period

164 citations , October 2014 in “Journal of Cutaneous and Aesthetic Surgery”

PRP injections increase hair density and satisfaction in androgenetic alopecia patients.

research The Dark Side of 5α-Reductase Inhibitors' Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer, and Depression

75 citations , January 2014 in “Korean Journal of Urology”

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

research The Effect of Autologous Activated Platelet Rich Plasma Injection on Pattern Hair Loss: Clinical and Histomorphometric Evaluation

183 citations , January 2014 in “BioMed Research International”

AA-PRP injections effectively increase hair count and thickness for male pattern hair loss.

research Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding

237 citations , June 2013 in “Nature Medicine”

A protein from certain immune cells is key for new hair growth after skin injury in mice.

research Dermal Papilla Cell Number Specifies Hair Size, Shape, and Cycling, and Its Reduction Causes Follicular Decline

211 citations , April 2013 in “Development”

More dermal papilla cells in hair follicles lead to larger, healthier hair, while fewer cells cause hair thinning and loss.

research Epithelial Wnt Ligand Secretion Is Required for Adult Hair Follicle Growth and Regeneration

170 citations , January 2013 in “Journal of Investigative Dermatology”

Wnt ligands are crucial for hair growth and repair.

research Autologous Platelet-Rich Plasma: A Potential Therapeutic Tool for Promoting Hair Growth

270 citations , July 2012 in “Dermatologic Surgery”

Platelet-rich plasma can potentially promote hair growth by stimulating cell growth and increasing certain proteins.

research Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells

85 citations , April 2012 in “PLOS ONE”

Valproic Acid helps regrow hair in mice and activates a hair growth marker in human cells.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations , May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

research Efficacy of 5% Minoxidil Versus Combined 5% Minoxidil and 0.01% Tretinoin for Male Pattern Hair Loss

43 citations , January 2007 in “American Journal of Clinical Dermatology”

Combined minoxidil and tretinoin solution works as well as regular minoxidil for male hair loss.

research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

520 citations , February 2001 in “Journal of Clinical Investigation”

VEGF helps hair grow and determines follicle size by increasing blood vessel growth.

2 / 2 results

research Duo-Role Platelet-Rich Plasma: Temperature-Induced Fibrin Gel and Growth Factors' Reservoir for Microneedles to Promote Hair Regrowth

February 2023 in “Journal of Advanced Research”

A new method using Platelet-rich Plasma (PRP) in a microneedle can promote hair regrowth more efficiently and is painless, minimally invasive, and affordable.

research Microneedling for the Treatment of Hair Loss

58 citations , April 2018 in “Journal of The European Academy of Dermatology and Venereology”

Microneedling can help stimulate hair growth, especially when used with other treatments, but it's not better than existing therapies.