Duo-Role Platelet-Rich Plasma: Temperature-Induced Fibrin Gel and Growth Factors' Reservoir for Microneedles to Promote Hair Regrowth

    February 2023 in “ Journal of Advanced Research
    Yang Sun, Lunan Yang, Lijuan Du, Yi Zhou, Kaige Xu, Jian Chen, Ye He, Qian Qu, Yong Miao, Malcolm Xing, Zhiqi Hu
    Image of study
    TLDR A new method using Platelet-rich Plasma (PRP) in a microneedle can promote hair regrowth more efficiently and is painless, minimally invasive, and affordable.
    The study introduces a new method for promoting hair regrowth using temperature-sensitive Platelet-rich Plasma (PRP) induced fibrin gel incorporated in a detachable transdermal microneedle (MN). The PRP gel, combined with gelatin methacryloyl (GelMA), allows for sustained release of growth factors (GFs) such as VEGF, PDGF, and TGF-β around the hair follicles for 4-6 days, promoting hair regrowth in mice models. The PRP-MNs were found to be convenient, minimally invasive, painless, inexpensive to manufacture, storable, and effective in boosting hair regeneration. In vivo experiments showed that PRP-MNs induced hair regrowth more efficiently than other methods, with 77% hair regrowth after 15 days compared to 52.3% in the PRP group. The study concluded that PRP-MNs provide a painless, minimally invasive, and sustainable effect of PRP for hair regrowth.
    Discuss this study in the Community →

    Research cited in this study

    36 / 36 results

    Related Community Posts Join

    6 / 77 results

      community Hairloss after doing PRF treatment

      in Treatment  2 upvotes 1 year ago
      The conversation is about the potential risk of permanent hair loss from PRP (platelet rich plasma) treatments and whether PRF (platelet rich fibrin) carries the same risk. The user is seeking information on this topic.

      community Do Platelet-rich plasma, PRP work?

      in Research/Science  14 upvotes 1 year ago
      Someone's brother tried Platelet-rich plasma (PRP) for hair loss; it had minimal effect on hair but improved skin appearance. Microneedling at home was suggested as a more sustainable alternative.

      community Thoughts on platelet-rich plasma therapy

      in Treatment  3 upvotes 3 weeks ago
      Platelet-rich plasma (PRP) therapy for hair loss is expensive, painful, and often ineffective, with mixed reviews on its benefits. Alternatives like minoxidil, finasteride, and hair transplants are suggested as more reliable options.

      community Why can't you drink caffeine after PRP?

      in Treatment  9 upvotes 2 years ago
      The conversation discusses avoiding caffeine after Platelet-Rich Plasma (PRP) treatment for hair loss because caffeine is a vasoconstrictor, which can reduce blood flow and hinder the healing process that PRP aims to promote.

      community I just made my own PRP - DIY PRP

      in Research/Science  549 upvotes 1 year ago
      The post and conversation are about a user who made their own Platelet-Rich Plasma (PRP) for hair loss treatment at home, using their own blood and a centrifuge. The responses vary, with some users supporting the DIY approach to save money, others expressing concern about the safety and effectiveness of the method, and a few joking about the lengths people will go to combat hair loss.

      community Anyone have PRP/Exosome results to share?

      in Treatment  3 upvotes 1 year ago
      Considering alternative treatments to hair loss, such as platelet-rich plasma (PRP) and exosome therapy, instead of using medications like minoxidil, finasteride/dutasteride.

    Related Research

    2 / 2 results