Transdermal Finasteride Delivery via Powder-Carrying Microneedles with a Diffusion Enhancer to Treat Androgenetic Alopecia

    November 2019 in “ Journal of Controlled Release ”
    Suyong Kim, Jaehong Eum, Huisuk Yang, Hyungil Jung
    Studysummary In this study, researchers developed a new self-administered finasteride delivery system using powder-carrying microneedles that improved hair growth efficacy and addressed safety concerns compared to topical finasteride gel by allowing sustained intradermal release of the drug for three days with a single application.
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    Research cited in this study 17

    1. Microneedling for the Treatment of Hair Loss Journal of The European Academy of Dermatology and Venereology · 2017
    2. Response to Microneedling Treatment in Men with Androgenetic Alopecia Who Failed to Respond to Conventional Therapy Indian Journal of Dermatology · 2015
    3. Topical Formulations Containing Finasteride: In Vitro Permeation/Penetration Study and In Vivo Pharmacokinetics in Hairless Rat Journal of Pharmaceutical Sciences · 2014
    4. Design and In Vitro Evaluation of Finasteride-Loaded Liquid Crystalline Nanoparticles for Topical Delivery Aaps Pharmscitech · 2012
    5. Alopecia: Evaluation and Treatment Clinical, Cosmetic and Investigational Dermatology · 2011
    6. Effect of Charge Carrier Lipid on Skin Penetration, Retention, and Hair Growth of Topically Applied Finasteride-Containing Liposomes Biomolecules & Therapeutics · 2011
    7. Enhancement of Percutaneous Absorption of Finasteride by Cosolvents, Cosurfactant, and Surfactants Pharmaceutical Development and Technology · 2009
    8. The Effect of Methylsulfonylmethane on Hair Growth Promotion of Magnesium Ascorbyl Phosphate for the Treatment of Alopecia Biomolecules & therapeutics · 2009
    9. Development of Liposomal Systems of Finasteride for Topical Applications: Design, Characterization, and In Vitro Evaluation Pharmaceutical Development and Technology · 2007
    10. Enhancement of Follicular Delivery of Finasteride by Liposomes and Niosomes International Journal of Pharmaceutics · 2006
    11. Simultaneous Effects of Tocopheryl Polyethylene Glycol Succinate on Local Hair Growth Promotion and Systemic Absorption of Topically Applied Minoxidil in a Mouse Model International Journal of Pharmaceutics · 2005
    12. Psychological Effect, Pathophysiology, and Management of Androgenetic Alopecia in Men Mayo Clinic Proceedings · 2005
    13. Finasteride in the Treatment of Androgenetic Alopecia Expert Opinion on Pharmacotherapy · 2004
    14. Genetic Basis of Male Pattern Baldness Journal of Investigative Dermatology · 2003
    15. Minoxidil vs Finasteride in the Treatment of Men With Androgenetic Alopecia Archives of Dermatology · 2003
    16. Androgenetic Alopecia: Pathogenesis and Potential for Therapy Expert Reviews in Molecular Medicine · 2002
    17. Finasteride Drugs · 1999

    Related research 10

    1. Hair Loss in Lichen Planopilaris and Frontal Fibrosing Alopecia: Not Always Irreversible Skin appendage disorders · 2020
    2. Transdermal Finasteride Delivery via Powder-Carrying Microneedles with a Diffusion Enhancer to Treat Androgenetic Alopecia Journal of Controlled Release · 2019
    3. Transdermal Delivery of a New Hair Growth Promoting Solution in Patients with Hair Loss International Journal of Case Reports and Images · 2019
    4. Frontal Fibrosing Alopecia Treatment Options Intractable & Rare Diseases Research · 2016
    5. Finasteride in the Treatment of Female Androgenic Alopecia PharmaTutor · 2014
    6. Global Photographic Assessment of Men Aged 18 to 60 Years with Male Pattern Hair Loss Receiving Finasteride 1 mg or Placebo Journal of The American Academy of Dermatology · 2012
    7. Androgens and Alopecia Molecular and Cellular Endocrinology · 2002
    8. Treatments for Androgenetic Alopecia and Alopecia Areata Drugs · 2001
    9. Finasteride in the Treatment of Men with Frontal Male Pattern Hair Loss Journal of The American Academy of Dermatology · 1999
    10. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998