Topical Formulations Containing Finasteride: In Vitro Permeation/Penetration Study and In Vivo Pharmacokinetics in Hairless Rat

June 2014 in “ Journal of Pharmaceutical Sciences ”

Daniela Monti, Silvia Tampucci, Susi Burgalassi, Patrizia Chetoni, Carla Lenzi, Andrea Pirone, Federico Mailland

finasteride topical formulations cutaneous depot hair bulbs systemic absorption hair loss Propecia

TLDR Finasteride cream helps hair growth with less side effects.

The study evaluated the use of topical formulations containing finasteride for the treatment of hair loss. The selected formulation, P-08-016, was found to promote a high level cutaneous depot of finasteride in the region surrounding the hair bulbs while minimizing systemic absorption, making it a potential alternative to systemic therapy for the treatment of hair loss. Further studies are needed to verify the exact quantity of drug retained inside the hair bulbs.

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Research cited in this study

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research Topical Formulations Containing Finasteride: In Vitro Permeation/Penetration Study and In Vivo Pharmacokinetics in Hairless Rat

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Finasteride cream helps hair growth with less side effects.