Topical Formulations Containing Finasteride: In Vitro Permeation/Penetration Study and In Vivo Pharmacokinetics in Hairless Rat

August 2014 in “ Journal of Pharmaceutical Sciences ”

Daniela Monti, Silvia Tampucci, Susi Burgalassi, Patrizia Chetoni, Carla Lenzi, Andrea Pirone, Federico Mailland

finasteride topical formulations cutaneous depot hair bulbs systemic absorption hair loss Propecia

TLDR Finasteride cream helps hair growth with less side effects.

The study evaluated the use of topical formulations containing finasteride for the treatment of hair loss. The selected formulation, P-08-016, was found to promote a high level cutaneous depot of finasteride in the region surrounding the hair bulbs while minimizing systemic absorption, making it a potential alternative to systemic therapy for the treatment of hair loss. Further studies are needed to verify the exact quantity of drug retained inside the hair bulbs.

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research Topical Formulations Containing Finasteride: In Vitro Permeation/Penetration Study and In Vivo Pharmacokinetics in Hairless Rat

23 citations , August 2014 in “Journal of Pharmaceutical Sciences”

Finasteride cream helps hair growth with less side effects.

Topical Formulations Containing Finasteride: In Vitro Permeation/Penetration Study and In Vivo Pharmacokinetics in Hairless Rat

Cited in this study

research Alopecia: Evaluation and Treatment

research Comparing the Therapeutic Effects of Finasteride Gel and Tablet in Treatment of Androgenetic Alopecia

research In Vitro Percutaneous Permeation and Skin Accumulation of Finasteride Using Vesicular Ethosomal Carriers

research Development of Liposomal Systems of Finasteride for Topical Applications: Design, Characterization, and In Vitro Evaluation

research Enhancement of Follicular Delivery of Finasteride by Liposomes and Niosomes

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