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research Herbal nano-formulations for topical delivery

36 citations , September 2019 in “Journal of Herbal Medicine”

This review explores research on nanoformulations for enhancing the topical delivery of herbal medicines, noting potential benefits like improved bioavailability and sustained delivery, and emphasizes the need for safety and toxicity guidelines in developing these novel drug delivery systems.

research Topical Formulations Containing Finasteride. Part I: In Vitro Permeation/Penetration Study and In Vivo Pharmacokinetics in Hairless Rat

23 citations , June 2014 in “Journal of Pharmaceutical Sciences”

This study found that the HPCH-based formulation P-08–016 may facilitate finasteride deposition in the dermis, potentially offering an alternative to systemic therapy by minimizing systemic absorption.

research Penetration Enhancement of Topical Formulations

22 citations , April 2018 in “Pharmaceutics”

This special issue reviews current challenges and innovative solutions for enhancing the penetration of topical formulations for human skin, reporting no new results.

research Topical Formulations Containing Finasteride. Part II: Determination of Finasteride Penetration into Hair Follicles using the Differential Stripping Technique

14 citations , June 2014 in “Journal of Pharmaceutical Sciences”

This study validated the differential stripping technique on hairless rat skin and found that the P-08–016 formulation delivered more finasteride to the epidermis and appendages compared to P-10–008.

research In Vitro Release of Minoxidil From Topical Formulations

2 citations , November 1987 in “Archives of Dermatology”

This study found that minoxidil was released 50% less from creams than from lotions, with a similar release profile across different lotion formulations, suggesting a specific vehicle composition for topical use.

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Community Join

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community Topical fin formulation question

in Finasteride 91 upvotes 1 year ago

A user is making a homemade topical finasteride solution by dissolving crushed finasteride tablets in ethanol and PG. They are unsure if the final solution maintains the intended concentration after filtering and are considering adding more ethanol to ensure accuracy.

community Ashwagandha Topical Formulation - A 2023 Study

9 upvotes 2 years ago

Ashwagandha topical formulation may increase hair density and reduce hair loss, but results seem too good to be true due to a small sample size. Users are skeptical about its effectiveness and are experimenting with different application methods.

community Topical finasteride in liposomal formulation

6 upvotes 6 years ago

Topical finasteride in a liposomal formulation reduces systemic absorption compared to ethanol solutions. The user is seeking sources for such products, noting that popular options like morr-f are not liposomal.

community Different Topical Dutasteride Formulations

3 upvotes 3 years ago

The conversation discusses the best vehicle for topical dutasteride, comparing Trichosol, Transcutol, and a gel version. It also mentions using Transcutol with ethanol to enhance transdermal delivery of Bimatoprost.

community Nuclear topical fin formulation?

1 upvotes 1 year ago

The conversation discusses a hair loss treatment involving oral minoxidil, topical finasteride, and a custom topical formulation with minoxidil, cetirizine, finasteride, progesterone, and hydrocortisone. The user seeks advice on the effectiveness of these ingredients for diffuse thinning.

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Learn

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learn Tofacitinib

How does tofacitinib differ when used orally versus topically in hair loss treatment research? Oral tofacitinib acts on immune signalling throughout the body and has more published regrowth data in alopecia areata (from small studies without placebo groups), alongside an FDA boxed warning; topical tofacitinib aims to act only on the scalp, but the human evidence is a handful of small compounded-formulation studies with no large randomized trial. Neither route is approved for hair loss, and regrowth generally reverses after treatment stops.

learn Minoxidil

Vasodilator used on the scalp and, at low doses, as a tablet

learn Finasteride

Popular 5-alpha reductase inhibitor that lowers DHT, taken as a pill or used topically

learn Neem Oil

Oil from the neem tree, used in traditional remedies

learn Cetirizine

Is topical cetirizine effective for androgenetic alopecia in women? Topical cetirizine is not an approved product and its use for female-pattern hair loss is off-label. The evidence is one small pilot study in mixed-sex patients and one randomized trial in 66 women where cetirizine was added to minoxidil; it is unproven on its own.

learn Valproic acid

How is valproic acid being explored differently in topical hair products compared to its traditional oral medical use? Topical valproic acid is being studied for local effects on the hair follicle rather than the whole-body effects of the oral drug. The human evidence is one small randomized 24-week trial of an 8.3% spray; no topical valproate product is approved for hair loss.

learn Bicalutamide

Is topical bicalutamide a safer alternative to finasteride? There is no published human trial of topical bicalutamide for hair loss, and no licensed topical product exists, so it cannot be called safer than finasteride — or shown to work at all. Oral finasteride has decades of trial data with a documented side-effect profile, and topical finasteride has a phase III trial behind it.

learn Rapamycin

Does topical rapamycin actually help reactivate dormant hair follicles? No study in living people has shown that topical rapamycin reactivates hair follicles; the evidence is from mice and cultured follicles.

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