Topical finasteride may have higher systemicabsorption and lower efficacy when using a Propylene Glycol/Ethanol formulation compared to the hydroxypropyl chitosan (HPCH) formulation. The safety profile of topical finasteride relies heavily on the HPCH formulation, and using standard solutions might lead to different pharmacokinetics.
The conversation discusses using RU58841 as a topical treatment for hair loss, with some users reporting no systemic issues. The original poster is considering RU58841 due to limited progress with dutasteride and oral minoxidil.
The conversation is about whether to use gloves when applying 5% RU58841 to avoid systemicabsorption and if washing hands with water is sufficient. Users question the concern, noting it is applied to the scalp.
Topical RU58841 is discussed for hair loss treatment, with a focus on brands available in Europe that have low systemicabsorption. Users suggest mixing your own solution to control vehicle and dosage, and mention different brands like Actifolic and Biolabshop.
Microneedling before applying topical finasteride or dutasteride may enhance their effectiveness by increasing local absorption in the scalp, despite concerns about systemicabsorption. Users discuss combining this method with oral treatments and minoxidil, noting potential benefits and side effects.