The conversation is about whether to use gloves when applying 5% RU58841 to avoid systemicabsorption and if washing hands with water is sufficient. Users question the concern, noting it is applied to the scalp.
The conversation is about using distilled water as a solvent for topical finasteride to reduce systemicabsorption. The user is considering avoiding ethanol and propylene glycol to achieve this.
The conversation discusses the potential of using topical estrogen treatments for hair loss without systemicabsorption, highlighting challenges and possible solutions like using estriol. It also mentions other treatments like topical finasteride, microneedling, and scalp massage, while noting the limitations and side effects of current options.
The conversation discusses the effectiveness and systemicabsorption of Topilutamide/Fluridil/Eucapil and topical Dutasteride for hair loss. Users are sharing their experiences and seeking success stories with these treatments.
Topical finasteride in a liposomal formulation reduces systemicabsorption compared to ethanol solutions. The user is seeking sources for such products, noting that popular options like morr-f are not liposomal.
Topical minoxidil can cause increased body hair due to systemicabsorption, varying by individual skin sensitivity. The user seeks experiences and solutions to prevent this side effect.
Dr. Kyle Gillet mentioned on Dr. Andrew Huberman's podcast that dutasteride mesotherapy blocks DHT conversion only in the scalp and is the most promising topical treatment. Users discussed concerns about systemicabsorption and the practicality of dutasteride injections.
The conversation discusses the potential benefits of creating a hydrophobic version of finasteride to reduce systemic side effects while maintaining scalp health. It compares this idea to fluridil, which is designed to be hydrophobic and has less systemicabsorption.
Topical dutasteride is considered for hair loss, but concerns about systemicabsorption and side effects like reduced libido are common. Users have mixed results, with some preferring oral finasteride or dutasteride despite side effects, while others find topical treatments beneficial but challenging.
Using both oral and topical minoxidil is likely safe, but be cautious of increased systemicabsorption. The best tretinoin dosage to enhance minoxidil effectiveness is not specified.
Adding tretinoin to a minoxidil routine can cause initial hair shedding, which may be normal as it potentially increases minoxidil's efficacy. Users suggest being cautious with tretinoin application, especially around microneedling, to avoid increased systemicabsorption.
Topical dutasteride is suggested as a low side-effect treatment for hair loss, with a proposed dose of 0.025% 1ml/day. It is considered better than finasteride due to its even inhibition of DHT isoforms and lower systemicabsorption.
Optimal microneedling routine is 1.25mm once a week with Dr Pen 36 needles. Applying Minoxidil right after microneedling may increase systemicabsorption risk.
Minoxidil may age skin by slowing collagen synthesis, but using collagen peptides and a basic skincare routine might counteract this. Foam minoxidil could reduce systemicabsorption and avoid alcohol-related side effects.
The user is considering topical Saw Palmetto or Pumpkin Seed Oil due to sensitivity to finasteride and cost issues. They also use dermastamping for Minoxidil absorption and seek advice on timing to avoid systemicabsorption.
The user is using 0.1% dutasteride, 1% minoxidil with 2% procapil and 0.005% caffeine in the morning, and 1% minoxidil with 2% procapil and 0.01% tretinoin at night. They are concerned about the solution vehicle's effectiveness in preventing systemicabsorption and ensuring the products stay around the hair follicles.
User discusses topical liposomal finasteride for hair loss, hoping to avoid breast growth side effect. Conversation includes using minoxidil, fluridil, and dermarolling, and mentions minimal systemicabsorption of liposomal finasteride.
RU58841 is used topically to prevent hair loss by blocking DHT, with suggestions to drink grapefruit juice, take breaks, avoid microneedling, and use lower concentrations to reduce side effects. Users discuss applying it at night to minimize systemicabsorption.
A user is seeking advice on a new topical hair loss treatment containing Minoxidil 3%, Finasteride 0.3%, Progesterone 1%, Hydrocortisone butyrate 0.1%, and Ketoconazole 0.5%. They are concerned about the systemicabsorption of Finasteride and plan to do blood tests and a spermiogram before starting.
Kintor's GT20029, a treatment for hair loss, has completed Phase 1 successfully, showing promise as an androgen receptor degrader that could potentially regrow hair. It is considered more effective than Pyrilutamide, with infrequent dosing and minimal systemicabsorption.
The conversation discusses a prescribed hair loss treatment combining 12.5% minoxidil with tretinoin, azelaic acid, and topical finasteride, costing $55 a month. One user criticizes the packaging for degrading tretinoin, another suggests it's an overpriced option and recommends topical dutasteride as an alternative due to its higher molecular weight and lower systemicabsorption.
Kintor Pharmaceutical's Phase 2 results with the drug Pyrilutamide, a potential alternative to 5-ARI drugs like Finasteride and Dutasteride but without the side effects. It could be used in combination with other topical treatments such as Minoxidil. The safety of the drug has been demonstrated in 6 months of use, however there are still questions about long term efficacy and systemicabsorption.
The conversation discusses how the absorption rate of topical finasteride varies and is not equivalent to its oral form, with only a small percentage reaching the scalp. It also mentions that minoxidil in high concentrations is used topically because only a small amount is absorbed.
The conversation is about whether topical finasteride and minoxidil need to be applied directly to the affected areas of the scalp or if they can be spread through blood vessels. It also asks how long topical finasteride remains on a pillow.
The conversation is about using RU58841 and microneedling (1.5mm) for hair loss. The user seeks advice on whether to avoid applying RU58841 on microneedling days to prevent it from becoming systemic.
The conversation discusses using estradiol mesotherapy to replicate hormone replacement therapy results while minimizing systemic exposure. It also covers the use of Spironolactone cream, which reportedly has no systemic side effects, and the potential risks of using bicalutamide and Spironolactone in men.
A user suggests making a potent sulforaphane topical to degrade DHT and promote hair growth. Another user notes that sulforaphane's low molecular weight might also lower systemic DHT.
Topical finasteride is considered a safer option for hair regrowth with fewer systemic side effects compared to oral finasteride. Some users report similar efficacy and side effects between topical and oral treatments, while others prefer topical due to reduced systemic exposure.
The conversation discusses using ketoconazole, an anti-androgen, for hair loss and whether mesotherapy with dermarolling could enhance its absorption into the scalp. The user questions if the typical 2% ketoconazole shampoo dose would be effective when used after dermarolling to target androgen receptors in the scalp.
