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Glossary Systemic Diseases

conditions affecting multiple organs or the entire body

Systemic diseases are conditions that affect multiple organs or the entire body, rather than being confined to a single location. Examples include diabetes, lupus, and rheumatoid arthritis. These diseases often involve complex interactions between various bodily systems and can lead to widespread symptoms and complications.

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Research

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research ASSOCIATION OF SYSTEMIC LUPUS ERYTHEMATOSUS AND CHRONIC GRANULOMATOUS DISEASE IN ADULTS: REPORT OF 2 CASES

May 2025 in “The Journal of Rheumatology”

This report describes two cases where female patients with chronic granulomatous disease developed manifestations of systemic lupus erythematosus, highlighting a rare association that may influence clinical evaluation and treatment planning.

research Low disease activity—irrespective of serologic status at baseline—associated with reduction of corticosteroid dose and number of flares in patients with systemic lupus erythematosus treated with belimumab: A real-life observational study

70 citations , February 2018 in “Seminars in Arthritis and Rheumatism”

This study found that belimumab helped achieve low disease activity in over 40% of systemic lupus erythematosus patients in real-life settings, alongside reduced corticosteroid use and fewer flares.

research A report on neglected case of systemic lupus erythematosus presenting by Degos’ skin disease and diffuse non-scarring alopecia with dramatic response to treatment

April 2024 in “African Journal of Biological Sciences”

In this case report, a 38-year-old woman with Degos disease and non-scarring alopecia experienced significant hair regrowth with the current treatment protocol, highlighting its potential effectiveness in such complex conditions.

A Neglected Case of Systemic Lupus Erythematosus Presenting with Degos' Skin Disease and Diffuse Non-Scarring Alopecia with Dramatic Response to Treatment, Clinically and Dermoscopically

research A Neglected case of Systemic lupus erythematosus presenting by Degos’ skin disease and diffuse non-scarring alopecia with dramatic response to treatment, clinically and dermoscopy.

April 2024 in “African Journal of Biological Sciences”

This case report describes a patient with systemic lupus erythematosus who developed Degos disease and non-scarring alopecia, highlighting dermoscopy's role in diagnosis and treatment prognosis.

Systemic Autoimmune Diseases: Insights and Advances

research Systemic Autoimmune Diseases

10 citations , January 2013 in “Clinical and developmental immunology/Clinical & developmental immunology”

This article is a special issue that reviews current research on the pathogenesis, diagnosis, and treatment of systemic autoimmune diseases, but it does not present new results.

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community If PP405 goes systemic this would be quite catastrophic

in Research/Science 4 upvotes 1 year ago

Concerns about the potential systemic effects and safety of PP405 for hair loss, with discussions on its comparison to existing treatments like finasteride and minoxidil. Users express skepticism about untested research chemicals and emphasize the importance of clinical trials to ensure safety and efficacy.

community Any treatment not nuking systemic DHT levels?

16 upvotes 7 months ago

Hair loss treatments that avoid significantly lowering systemic DHT levels, focusing on topical options like dutasteride mesotherapy, minoxidil, and ketoconazole. The user is exploring alternatives like KX-826 and RU58841 due to concerns about hormone levels.

community Pattern hair loss before the age of 35 is associated with higher chances of prostate cancer, cardiovascular diseases, and metabolic syndrome later in life

1075 upvotes 3 months ago

Pattern hair loss before age 35 may be linked to higher risks of prostate cancer, cardiovascular diseases, and metabolic syndrome later in life. Finasteride is discussed as a treatment that may lower PSA levels and potentially prevent prostate issues.

community How finasteride lowers brain's happiness steroid allopregnanolone and causes depression: systemic dihydroprogesterone crosses blood brain barrier, you don't even need finasteride and brain 5ar for that

288 upvotes 1 year ago

Finasteride may lower allopregnanolone levels, potentially affecting mood, but many users report improved mental health due to reduced hair loss. Experiences with finasteride and dutasteride vary, with some experiencing side effects and others finding them beneficial for hair retention and overall happiness.

community Topical dutasteride significantly outperforms oral finasteride

in Research/Science 65 upvotes 1 year ago

Topical dutasteride 0.05% is reported to outperform oral finasteride with minimal side effects, but concerns about study bias exist due to company funding. Some users report mixed results with topical dutasteride, noting issues with skin penetration and systemic absorption.

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