Systemic Absorption and Pharmacokinetics of Five Novel Topical Dermatologic Agents: A Review
December 2025
in “
JEADV Clinical Practice
”
TLDR These new skin treatments are safer and more effective with minimal side effects.
This review evaluates the pharmacokinetics, pharmacodynamics, and systemic absorption of five novel topical dermatologic agents: ruxolitinib cream, tirbanibulin ointment, clascoterone cream, minocycline foam, and tapinarof cream. These agents, used for conditions like acne and atopic dermatitis, show low plasma concentrations and bioavailability, indicating minimal systemic absorption and a low risk of adverse effects. They represent a significant advancement in dermatologic care by improving safety, tolerability, and efficacy compared to traditional treatments. However, further research is needed to assess their long-term safety and efficacy.
