Developing a JAK Inhibitor for Targeted Local Delivery: Ruxolitinib Cream

    July 2021 in “ Pharmaceutics ”
    Paul Smith, Wenqing Yao, Stacey Shepard, Maryanne Covington, James A. Lee, Jennifer H. Lofland, Ahmad Naim, Trupti Sheth, Bhavnish Parikh, Swamy Yeleswaram
    TLDR Ruxolitinib cream effectively targets and treats inflammatory skin diseases.
    The article discussed the development of ruxolitinib cream, a selective JAK1/2 inhibitor designed for targeted local delivery to treat immune-mediated dermatologic diseases. The JAK signaling pathway was crucial for inflammatory cytokine signaling, and ruxolitinib was developed with low nanomolar potency specific to JAK1 and 2, minimizing effects on non-JAK kinases. Incyte Corporation formulated an oil-in-water emulsified cream for topical use, which was studied in conditions like psoriasis, alopecia areata, atopic dermatitis, and vitiligo. This cream represented a novel approach to directly treat cytokine-driven inflammatory skin diseases.
    Discuss this study in the Community →

    Research cited in this study

    6 / 6 results

    Related Community Posts Join

    3 / 3 results

      community What else is good. Besides the big 3.

      in Chat  35 upvotes 1 year ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community Ruxolitinib - Start of a case study

      in Research/Science  10 upvotes 1 year ago
      The conversation is about a user trying a new hair loss treatment, Ruxolitinib, alongside their existing regimen of finasteride, minoxidil, ketoconazole shampoo, and microneedling. They plan to apply Ruxolitinib to their temples daily for 1-2 months.

      community No hair, don't care! [24/F] :)

       59 upvotes 9 years ago
      A woman with alopecia universalis shares her positive experience of being bald, finding it freeing and less worrisome. She also discusses her skincare routine using Korean products.

    Related Research

    1 / 1 results