Alopecia Areata: Overview and Insights from January 2018

    Lauren C. Strazzulla, Eddy Hsi Chun Wang, Lorena Avila, Kristen Lo Sicco, Nooshin Brinster, Angela M. Christiano, Jerry Shapiro
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    TLDR Alopecia areata is an autoimmune condition causing hair loss, influenced by genetics, stress, and diet, and may be prevented by a high soy oil diet.
    The document from January 2018 provides an overview of Alopecia areata (AA), a common autoimmune hair loss condition affecting both sexes and all age groups, with a prevalence of 0.1% to 0.2%. It is characterized by immune-mediated destruction of hair follicles and inflammatory pathways upregulation. Trichoscopy can be used for diagnosis, showing specific features like exclamation point hairs. The severity of AA correlates with CD8+ T cell density, and genetic studies have implicated various immune-related genes. The C3H/HeJ mouse model has been instrumental in AA research. Factors such as atopy, other autoimmune conditions, stress, and diet may contribute to the risk of developing AA. A high soy oil diet may prevent AA by modulating inflammatory activity. The document also discusses the role of the JAK/STAT pathway in AA and suggests that stress hormones and diet can influence the condition's development.
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