Alopecia Areata: Overview and Insights from January 2018
January 2018
in “
Journal of The American Academy of Dermatology
”
Alopecia areata autoimmune hair loss immune-mediated destruction hair follicles inflammatory pathways Trichoscopy exclamation point hairs CD8+ T cell immune-related genes C3H/HeJ mouse model atopy autoimmune conditions stress diet soy oil diet JAK/STAT pathway stress hormones AA immune system hair loss inflammation hair diagnosis immune cells genetic factors mouse model allergies autoimmune diseases dietary factors soy diet JAK pathway
TLDR Alopecia areata is an autoimmune condition causing hair loss, influenced by genetics, stress, and diet, and may be prevented by a high soy oil diet.
The document from January 2018 provides an overview of Alopecia areata (AA), a common autoimmune hair loss condition affecting both sexes and all age groups, with a prevalence of 0.1% to 0.2%. It is characterized by immune-mediated destruction of hair follicles and inflammatory pathways upregulation. Trichoscopy can be used for diagnosis, showing specific features like exclamation point hairs. The severity of AA correlates with CD8+ T cell density, and genetic studies have implicated various immune-related genes. The C3H/HeJ mouse model has been instrumental in AA research. Factors such as atopy, other autoimmune conditions, stress, and diet may contribute to the risk of developing AA. A high soy oil diet may prevent AA by modulating inflammatory activity. The document also discusses the role of the JAK/STAT pathway in AA and suggests that stress hormones and diet can influence the condition's development.
