Identification of Differentially Expressed miRNAs in Alopecia Areata That Target Immune-Regulatory Pathways

    March 2017 in “ Genes and immunity ”
    E H C Wang, Gina M. DeStefano, Anjni Patel, Esther Drill, Sivan Harel, Carolina Cela, Masoud Tavazoie, Angela M. Christiano
    TLDR Certain microRNAs may help treat alopecia areata by targeting immune pathways.
    The document identified differentially expressed microRNAs (miRNAs) in alopecia areata that targeted immune-regulatory pathways. The study highlighted the role of cytotoxic T lymphocytes in driving alopecia areata and demonstrated that JAK inhibition could reverse the condition. The research underscored the genetic and environmental factors contributing to alopecia areata, supported by findings from genome-wide association studies and twin studies. Additionally, the document discussed the involvement of specific miRNAs in autoimmune diseases and their potential as therapeutic targets.
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