TLDR Epigenetic changes in blood cells may contribute to alopecia areata.
The study investigated epigenetic modifications in peripheral blood mononuclear cells (PBMCs) from 25 patients with alopecia areata (AA) and 20 healthy controls. It found increased DNA methylation and altered histone modifications in AA patients, with higher levels of DNMT1, MBD1, and MBD4 expression. Histone H3 acetylation was elevated, correlating with disease severity and RANTES (CCL5) mRNA expression, while histone H3 lysine 4 methylation was decreased. These epigenetic changes were linked to the deregulation of various epigenetic regulatory genes, suggesting they may contribute to the pathological immune responses in AA.
717 citations,
June 2010 in “Nature” Alopecia areata involves both innate and adaptive immunity, with specific genes linked to the disease.
391 citations,
January 2010 in “Journal of The American Academy of Dermatology” Half of people with Alopecia Areata may see hair regrowth within a year without treatment, but recovery is unpredictable.
69 citations,
July 2002 in “Clinical and Experimental Dermatology” Alopecia areata is influenced by genetics and immune system factors, and better understanding could improve treatments.
49 citations,
April 2000 in “Journal of The American Academy of Dermatology” Despite progress in treatment, the exact cause of Alopecia areata is still unknown.
5 citations,
May 2023 in “Frontiers in immunology” Environmental factors like diet and vitamin levels, especially Vitamin D, can affect autoimmune diseases differently, with lifestyle changes potentially improving outcomes.
January 2024 in “Frontiers in immunology” Histone modification is key in treating chronic inflammatory skin diseases.
15 citations,
December 2013 Men with more vanadium in their blood and who drink less soy milk are more likely to have hair loss.
290 citations,
December 2017 in “Journal of The American Academy of Dermatology” Alopecia areata is an autoimmune condition causing hair loss, influenced by genetics, stress, and diet, and may be prevented by a high soy oil diet.
April 2021 in “Sohag Medical Journal” Alopecia areata is an autoimmune condition causing hair loss, linked to genetic factors and immune system issues, with no cure yet.
