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GlossaryDNA Methyltransferase 1 (DNMT1)

maintains DNA methylation patterns during cell division

DNA Methyltransferase 1 (DNMT1) is an enzyme that plays a crucial role in maintaining DNA methylation patterns during cell division. It adds methyl groups to the cytosine bases of DNA, which can regulate gene expression by turning genes on or off. This process is essential for normal development, genomic stability, and cellular differentiation.

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research DNMT1-Mediated Methylation Inhibits MicroRNA-214-3p and Promotes Hair Follicle Stem Cell Differentiation Into Adipogenic Lineages

8 citations , October 2020 in “Stem cell research & therapy”

DNMT1 helps turn hair follicle stem cells into fat cells by blocking a specific microRNA.

research Regulation of Somatic Cell Reprogramming Through Inducible miR-302 Expression

308 citations , September 2010 in “Nucleic acids research”

Increasing mir-302 turns human hair cells into stem cells by changing gene regulation and demethylation.

Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability During Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1

research Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability During Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1

72 citations , July 2012 in “Journal of Investigative Dermatology”

Mice lacking a key DNA methylation enzyme in skin cells have a lower chance of activating stem cells necessary for hair growth, leading to progressive hair loss.

research Abnormal Epigenetic Modifications in Peripheral Blood Mononuclear Cells from Patients with Alopecia Areata

48 citations , September 2011 in “British Journal of Dermatology”

Epigenetic changes in blood cells may contribute to alopecia areata.

research DNA Methylation as an Epigenetic Memory Keeper During Skin Development and Regeneration

1 citations , January 2018 in “Stem cell biology and regenerative medicine”

DNA methylation is essential for skin and hair follicle development, and could be a target for treating skin diseases.

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