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GlossaryDNA Methyltransferase 1 (DNMT1)

maintains DNA methylation patterns during cell division

DNA Methyltransferase 1 (DNMT1) is an enzyme that plays a crucial role in maintaining DNA methylation patterns during cell division. It adds methyl groups to the cytosine bases of DNA, which can regulate gene expression by turning genes on or off. This process is essential for normal development, genomic stability, and cellular differentiation.

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Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability During Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1

research Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability During Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1

72 citations , July 2012 in “Journal of Investigative Dermatology”

Mice lacking a key DNA methylation enzyme in skin cells have a lower chance of activating stem cells necessary for hair growth, leading to progressive hair loss.

research Methylation of CpG Islands in Promoter of Type 2 5-Alpha Reductase and Implications of Finasteride Resistance for BPH Therapy

March 2016 in “European Urology Supplements”

Methylation in specific gene region causes finasteride resistance in some BPH patients.

research DNA Methyltransferases in Malar Melasma and Their Modification by Sunscreen with 4% Niacinamide, 0.05% Retinoic Acid, or Placebo

20 citations , April 2019 in “BioMed Research International”

Treatments with sunscreen and active ingredients can reduce skin hyperpigmentation by decreasing DNA methylation.

research DNMT1-Mediated Methylation Inhibits MicroRNA-214-3p and Promotes Hair Follicle Stem Cell Differentiation Into Adipogenic Lineages

8 citations , October 2020 in “Stem cell research & therapy”

DNMT1 helps turn hair follicle stem cells into fat cells by blocking a specific microRNA.

research Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability During Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1

1 citations , September 2012 in “Journal of Investigative Dermatology”

Aging reduces stem cell activation, leading to hair loss in mice lacking a specific enzyme.

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