DNMT1-Mediated Methylation Inhibits MicroRNA-214-3p and Promotes Hair Follicle Stem Cell Differentiation Into Adipogenic Lineages

October 2020 in “ Stem cell research & therapy ”

Fulai Jin, Min Li, Xuyang Li, Yunpeng Zheng, Kun Zhang, Xiaojun Liu, Bingjie Cai, Guangwen Yin

DNMT1 methylation microRNA-214-3p hair follicle stem cells adipogenic lineages MAPK1 p-ERK1/2 skin regeneration wound healing HFSc differentiation therapeutic applications hair growth regeneration therapies miR-214-3p stem cells fat cells ERK1/2 skin healing hair treatments

TLDR DNMT1 helps turn hair follicle stem cells into fat cells by blocking a specific microRNA.

The study concluded that DNMT1-mediated methylation inhibited microRNA-214-3p, promoting the differentiation of hair follicle stem cells (HFSc) into adipogenic lineages. This process involved the activation of the MAPK1/p-ERK1/2 axis, enhancing skin regeneration and wound healing in a mouse model. The findings underscored the crucial role of DNMT1 and miR-214-3p in HFSc differentiation, suggesting potential therapeutic applications for hair growth and regeneration therapies. The study involved HFScs from 9 patients and 8 mice per group, using various molecular biology techniques to elucidate these mechanisms.

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