Signal Integrator Function of CXXC5 in Cancer

    January 2025 in “ Cell Communication and Signaling ”
    Zihao An, Jing Wang, Chang Li, Chao Tang
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    TLDR CXXC5 can both suppress and promote cancer, making it a complex target for treatment.
    CXXC5, a member of the ZF-CXXC protein family, is a crucial regulator in cellular signaling networks, impacting processes like cell proliferation, differentiation, and apoptosis. It plays significant roles in cancer progression, acting as both a tumor suppressor and promoter depending on the cancer type, and is involved in pathways such as Wnt/β-catenin and TGF-β/BMP. CXXC5's inhibition has shown potential therapeutic applications in conditions like hair regeneration, skin healing, and bone formation. Its dual role in cancer necessitates careful consideration in treatment strategies, and further research is needed to fully understand its regulatory functions and potential as a diagnostic and therapeutic target.
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