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    Inhibiting the Cytosolic Function of CXXC5 Accelerates Diabetic Wound Healing by Enhancing Angiogenesis and Skin Repair

    August 2023 in “ Experimental & Molecular Medicine ”
    Eunhwan Kim, Seol Hwa Seo, Yumi Hwang … Kang‐Yell Choi
    Studysummary This study found that the CXXC5 protein is overexpressed in diabetic foot ulcer tissues, suppressing wound healing, and that the small molecule KY19334 accelerated healing in diabetic mice by activating the Wnt/β-catenin pathway.
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    Research cited in this study 6

    1. KY19382, A Novel Activator of Wnt/β-Catenin Signalling, Promotes Hair Regrowth and Hair Follicle Neogenesis British Journal of Pharmacology · 2021
    2. Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing Nature Communications · 2018
    3. Targeting of CXXC5 by a Competing Peptide Stimulates Hair Regrowth and Wound-Induced Hair Neogenesis Journal of Investigative Dermatology · 2017
    4. Wnt Signaling Induces Epithelial Differentiation During Cutaneous Wound Healing Organogenesis · 2015
    5. Cutaneous Wound Healing: Recruiting Developmental Pathways for Regeneration Cellular and Molecular Life Sciences · 2012
    6. Wnt Signaling and Injury Repair Cold Spring Harbor Perspectives in Biology · 2012