Targeting Wnt/β-Catenin Signaling and Its Interplay with TGF-β and Notch Signaling Pathways for the Treatment of Chronic Wounds

    April 2024 in “ Cell Communication and Signaling ”
    Dimakatso B Gumede, Heidi Abrahamse, Nicolette N. Houreld
    Studysummary This review highlights the role of the Wnt/β-catenin signaling pathway in wound healing, particularly in diabetic ulcers, discussing its interactions with other pathways and potential therapeutic strategies targeting this pathway, such as photobiomodulation.
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    Research cited in this study 12

    1. Inhibiting the Cytosolic Function of CXXC5 Accelerates Diabetic Wound Healing by Enhancing Angiogenesis and Skin Repair Experimental & Molecular Medicine · 2023
    2. Wnt/β-Catenin Signaling: Function, Biological Mechanisms, and Therapeutic Opportunities Signal Transduction and Targeted Therapy · 2022
    3. Wound Healing: A Cellular Perspective Physiological Reviews · 2018
    4. Wnt/β-Catenin and ERK Pathway Activation: A Possible Mechanism of Photobiomodulation Therapy with Light-Emitting Diodes That Regulate the Proliferation of Human Outer Root Sheath Cells Lasers in Surgery and Medicine · 2017
    5. Photobiomodulation of Human Dermal Fibroblasts In Vitro: Decisive Role of Cell Culture Conditions and Treatment Protocols on Experimental Outcome Scientific Reports · 2017
    6. Inhibition of β-Catenin Signaling in Dermal Fibroblasts Enhances Hair Follicle Regeneration During Wound Healing Development · 2016
    7. Wnt Signaling Induces Epithelial Differentiation During Cutaneous Wound Healing Organogenesis · 2015
    8. Wnt and Notch Signaling Pathway Involved in Wound Healing by Targeting c-Myc and Hes1 Separately Stem Cell Research & Therapy · 2015
    9. Cutaneous Wound Healing: Recruiting Developmental Pathways for Regeneration Cellular and Molecular Life Sciences · 2012
    10. Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells PLOS ONE · 2012
    11. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011
    12. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007

    Related research 1

    1. Temporal-Spatial Activation of Wnt-Signaling Within Type 1 and Type 2 Immunity During Wound Healing Journal of Investigative Dermatology · 2019