Wnt and Notch Signaling Pathway Involved in Wound Healing by Targeting c-Myc and Hes1 Separately

    June 2015 in “ Stem Cell Research & Therapy ”
    Yan Shi, Bin Shu, Ronghua Yang, Yingbin Xu, Bangrong Xing, Jian Liu, Lei Chen, Shaohai Qi, Xusheng Liu, Peng Wang, Jinming Tang, Julin Xie
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    TLDR Wnt and Notch signaling help wound healing by promoting cell growth and regulating cell differentiation.
    Shi et al. conducted a study on Sprague-Dawley rats to explore the roles of Wnt/ß-catenin and Notch signaling pathways in wound healing, focusing on their effects on epidermal stem cell proliferation, keratinocyte differentiation and migration, and follicle regeneration. The study found that activating these pathways with LiCl and rhNF-kB accelerated wound closure, improved healing quality, and enhanced hair follicle formation, while inhibiting them with DKK1 and DAPT delayed healing. Western blot analysis and histological examination showed that Wnt signaling targets c-Myc, promoting cell proliferation, while Notch signaling targets Hes1, regulating differentiation. The study concluded that Wnt and Notch signaling are important for wound repair, with their interaction being crucial for the regulation of the healing process. Further research is needed to understand the mechanisms of their interaction, which could lead to new treatments for delayed healing and scarring. The study was supported by the National Natural Science Foundation of China and the Guangdong Science and Technology Program Project Funds, with no competing interests declared by the authors.
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