Wnt and Notch Signaling Pathway Involved in Wound Healing by Targeting c-Myc and Hes1 Separately

    June 2015 in “ Stem Cell Research & Therapy ”
    Yan Shi, Bin Shu, Ronghua Yang … Julin Xie
    Studysummary This study found that activation or inhibition of Wnt/β-catenin and Notch signaling pathways in rats can alter wound healing, possibly by affecting epidermal stem cell activity and keratinocyte behavior.
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    Research cited in this study 9

    1. Cutaneous Wound Healing: Recruiting Developmental Pathways for Regeneration Cellular and Molecular Life Sciences · 2012
    2. Biochemistry of Epidermal Stem Cells Biochimica et Biophysica Acta (BBA) - General Subjects · 2012
    3. 25 Years of Epidermal Stem Cell Research Journal of Investigative Dermatology · 2012
    4. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    5. Wnt Signaling Induces Epithelial Differentiation During Cutaneous Wound Healing BMC Cell Biology · 2006
    6. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    7. Transient Activation of Beta-Catenin Signaling in Adult Mouse Epidermis Induces New Hair Follicles, Continuous Activation Maintains Tumors Development · 2004
    8. Deregulated Expression of c-Myc Depletes Epidermal Stem Cells Nature Genetics · 2001
    9. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000