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Glossary Dickkopf-related protein 4

regulates Wnt signaling, affecting hair follicle development and cycling

Dickkopf-related protein 4 (Dkk4) is a protein that plays a crucial role in regulating the Wnt signaling pathway, which is important for cell growth, development, and differentiation. In the context of hair biology, Dkk4 can influence hair follicle development and cycling, and its dysregulation has been associated with conditions like alopecia, where hair loss occurs.

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research 1332 Janus kinase inhibitor increases hair growth by increasing beta-catenin activity in outer root sheath cells

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that JAK1 and JAK2 inhibitors increase β-catenin activity in human hair follicle cells, suggesting an additional therapeutic mechanism for treating severe alopecia areata.

research 1365 Interest of Biotrinine®, a mix of Nasturtium officinale and Tropaeolum majus extracts, for chronic hair loss treatment

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

In a laboratory setting, this study found that Biotrinine® dry extract activated hair follicle growth pathways and increased certain growth factor secretions in human dermal papilla cells, suggesting potential benefits for treating chronic hair loss.

research Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately

113 citations , June 2015 in “Stem Cell Research & Therapy”

This study found that activation or inhibition of Wnt/β-catenin and Notch signaling pathways in rats can alter wound healing, possibly by affecting epidermal stem cell activity and keratinocyte behavior.

research Visible-to-Near IR Quantum Dot–Based Hypermulticolor High-Content Screening of Herbal Medicines for the Efficacy Monitoring of Hair Growth Promotion and Hair Loss Inhibition

14 citations , November 2012 in “SLAS discovery”

This study observed that certain herbal extracts may promote hair growth and inhibit hair loss in cell lines by affecting specific protein expressions similarly to minoxidil.

research Deciphering Early-Stage Molecular Mechanisms of Negative Pressure Wound Therapy in a Murine Model

2 citations , February 2024 in “International Journal of Molecular Sciences”

This study reported that in a mouse model, Negative Pressure Wound Therapy promotes wound healing by modulating inflammatory responses and increasing dickkopf-related protein 1, which encourages the differentiation of Hair Follicle Stem Cells into epidermal cells.

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community Fats on your Head to Stop Hair Loss?

140 upvotes 2 years ago

The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

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