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    Glossary Dickkopf-related protein 4

    regulates Wnt signaling, affecting hair follicle development and cycling

    Dickkopf-related protein 4 (Dkk4) is a protein that plays a crucial role in regulating the Wnt signaling pathway, which is important for cell growth, development, and differentiation. In the context of hair biology, Dkk4 can influence hair follicle development and cycling, and its dysregulation has been associated with conditions like alopecia, where hair loss occurs.

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    Research 30 of 534

    1. 1332 Janus kinase inhibitor increases hair growth by increasing beta-catenin activity in outer root sheath cells 2023
    2. 1365 Interest of Biotrinine®, a mix of Nasturtium officinale and Tropaeolum majus extracts, for chronic hair loss treatment 2018
    3. Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately Stem Cell Research & Therapy · 2015 · 113 citations
    4. Visible-to-Near IR Quantum Dot–Based Hypermulticolor High-Content Screening of Herbal Medicines for the Efficacy Monitoring of Hair Growth Promotion and Hair Loss Inhibition SLAS discovery · 2012 · 14 citations
    5. Deciphering Early-Stage Molecular Mechanisms of Negative Pressure Wound Therapy in a Murine Model International Journal of Molecular Sciences · 2024 · 2 citations
    6. Hair Growth Promoting Effects of Limosilactobacillus reuteri Isolated from Honeybee through Wnt/β-catenin Signal Transduction Journal of the Korean Society of Cosmetology · 2026
    7. Hair Growth Effect and the Mechanisms of Rosa rugosa Extract in DHT-Induced Alopecia Mice Model International Journal of Molecular Sciences · 2024
    8. Hair growth–promoting effects of Enz_MoriL on human dermal papilla cells through modulation of the Wnt/β-Catenin and JAK-STAT signaling pathways Archives of dermatological research · 2024
    9. Role of Dermal Factors Involved in Regulating the Melanin and Melanogenesis of Mammalian Melanocytes in Normal and Abnormal Skin International journal of molecular sciences · 2024
    10. Proteomics Characterization of Primary Human Oral Epithelial Cells Using a Novel Culture Technique for Use in Tissue Regeneration MOJ proteomics & bioinformatics · 2015
    11. DKK4 as a novel candidate marker for Zhexi Angora rabbit wool quality World Rabbit Science · 2026
    12. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007 · 171 citations
    13. Wnt signaling in skin organogenesis Organogenesis · 2008 · 72 citations
    14. Partial Proteasome Inhibitors Induce Hair Follicle Growth by Stabilizing β-Catenin Stem cells · 2013 · 3 citations
    15. Dickkopf-related Protein 2 Promotes Hair Growth by Upregulating the Wnt/β-catenin Signaling Pathway in Human Dermal Papilla Cells Annals of Dermatology · 2024 · 6 citations
    16. Therapeutic Potentiality of Celtis choseniana Nakai on Androgenic Alopecia through Repression of Androgen Action and Modulation of Wnt/β-catenin Signaling Natural product sciences · 2023
    17. 1343 Efficacy of asymmetric siRNA targeting androgen receptor for the treatment of androgenetic alopecia Journal of Investigative Dermatology · 2023
    18. Ectodysplasin-A2 induces dickkopf 1 expression in human balding dermal papilla cells overexpressing the ectodysplasin A2 receptor Biochemical and Biophysical Research Communications · 2020 · 4 citations
    19. Acquired curved hair is caused by fusion of multiple hair matrix cells Journal of Dermatological Science · 2024
    20. The Dickkopf Protein Family in Non-Neoplastic Disorders: Emerging Roles and Therapeutic Targeting Aging and Disease · 2026
    21. An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities Frontiers in Cell and Developmental Biology · 2020 · 23 citations
    22. Panax ginseng extract antagonizes the effect of DKK-1-induced catagen-ike changes of hair follicles International Journal of Molecular Medicine · 2017 · 15 citations
    23. Human umbilical cord blood mesenchymal stem cells engineered to overexpress growth factors accelerate outcomes in hair growth The Korean Journal of Physiology and Pharmacology · 2018 · 21 citations
    24. Hoxc13 polyglycine repeat gain-of-function drives mammalian integument evolution by altering targeted genes and interactions Research Square · 2026
    25. Expression of Signaling Components in Embryonic Eyelid Epithelium PloS one · 2014 · 5 citations
    26. SFRP2 augments Wnt/β-catenin signalling in cultured dermal papilla cells Experimental Dermatology · 2016 · 17 citations
    27. Paracrine Secreted Frizzled-Related Protein 4 Inhibits Melanocytes Differentiation in Hair Follicle Stem Cells International · 2017 · 8 citations
    28. Millet seed oil activates β–catenin signaling and promotes hair growth Frontiers in Pharmacology · 2023 · 1 citations
    29. Expression of the Wnt signaling pathway and hair follicle development in  Rex rabbits of different ages 2025
    30. Blockade of Androgen Markers Using a Novel Betasitosterol, Thioctic Acid and Carnitine-containing Compound in Prostate and Hair Follicle Cell-based Assays Phytotherapy Research · 2016 · 3 citations