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    GlossaryDickkopf-1 (DKK1)

    inhibits hair follicle formation, contributing to hair loss

    Dickkopf-1 (DKK1) is a protein that plays a crucial role in regulating cell signaling pathways, particularly the Wnt signaling pathway, which is important for cell growth and development. In the context of hair biology, DKK1 is known to inhibit hair follicle formation and is associated with conditions like androgenetic alopecia (pattern baldness), where its elevated levels can lead to hair loss.

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      community Nearly 3 years in and I'm on a mega growth spurt. Don't lose heart.

      in Chat  63 upvotes 1 year ago
      The user experienced subtle hair growth improvements using finasteride, dutasteride, and minoxidil over nearly three years, with notable progress at the temples. The front hairline shows quicker regrowth cycles, but the vertex and crown remain unchanged.

      community Trialing the probiotics BB536, PTA 6475 so you don’t have to

      in Research/Science  72 upvotes 2 weeks ago
      Probiotics like L. reuteri ATCC PTA 6475 and B. longum BB536 may improve hair growth and density by reducing inflammation and reversing DHT damage. The user is trialing these probiotics personally, ordering them from the U.S. to Canada, and plans to continue if no adverse effects occur.

      community Better Than Minoxidil? Topical Sodium Valproate

      in Research/Science  49 upvotes 4 months ago
      Topical sodium valproate may promote hair growth by inhibiting GSK3β, allowing beta-catenin to proliferate, but it has potential side effects and requires more research. The conversation also mentions skepticism about a product called Vdphlo1, which includes sodium valproate and other ingredients.

      community Has anyone used Magnesium L-Threonate ?

       71 upvotes 6 years ago
      Magnesium L-Threonate may help treat balding by reducing DKK-1 expression without affecting DHT. Users discuss its potential effectiveness and application methods, with some considering trying it topically.

      community GT20029 and PP405 the new fin and min that we been waiting for ?

      in Chat  31 upvotes 2 weeks ago
      PP405 and GT20029 are new hair loss treatments with different mechanisms from traditional options like Minoxidil and Finasteride. PP405 targets hair follicle stem cells to reactivate growth, while GT20029 works as an androgen receptor deleter, both requiring ongoing use for effectiveness.