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GlossaryDickkopf-1 (DKK1)

inhibits hair follicle formation, contributing to hair loss

Dickkopf-1 (DKK1) is a protein that plays a crucial role in regulating cell signaling pathways, particularly the Wnt signaling pathway, which is important for cell growth and development. In the context of hair biology, DKK1 is known to inhibit hair follicle formation and is associated with conditions like androgenetic alopecia (pattern baldness), where its elevated levels can lead to hair loss.

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research Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1, and Sfrp4

75 citations, March 2014 in “Journal of Investigative Dermatology”

Aging mice have slower hair regeneration due to changes in signal balance, but the environment, not stem cell loss, controls this, suggesting treatments could focus on environmental factors.

research DKK1 Mediated Inhibition of Wnt Signaling in Postnatal Mice Leads to Loss of TEC Progenitors and Thymic Degeneration

56 citations, February 2010 in “PLOS ONE”

Blocking Wnt signaling in young mice causes thymus shrinkage and cell loss, but recovery is possible when the block is removed.

research Perspectives on MicroRNAs Targeting DKK1 for Developing Hair Regeneration Therapy

12 citations, October 2021 in “Cells”

Targeting a protein that blocks hair growth with microRNAs could lead to new hair loss treatments, but more research is needed.

research DKK1-Targeting Cholesterol-Modified siRNA Implication in Hair Growth Regulation

1 citations, May 2023 in “Biochemical and Biophysical Research Communications”

Blocking DKK1 with siRNA can improve hair growth.

Platelet-Rich Plasma Contains High Concentrations of DKK1, A Potent Inhibitor of Wnt Signaling That Limits Bone Regeneration and Hair Growth

research Platelet-Rich Plasma Contains High Concentrations of DKK1, A Potent Inhibitor of Wnt Signaling That Limits Bone Regeneration and Hair Growth

January 2023 in “Journal of orthopedics & bone disorders”

Platelet-rich plasma may not be very effective for bone healing and hair growth due to a substance it contains that blocks these processes.

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community Nearly 3 years in and I'm on a mega growth spurt. Don't lose heart.

in Chat 63 upvotes 1 year ago

The user experienced subtle hair growth improvements using finasteride, dutasteride, and minoxidil over nearly three years, with notable progress at the temples. The front hairline shows quicker regrowth cycles, but the vertex and crown remain unchanged.

community Trialing the probiotics BB536, PTA 6475 so you don’t have to

in Research/Science 74 upvotes 3 weeks ago

Probiotics like L. reuteri ATCC PTA 6475 and B. longum BB536 may improve hair growth and density by reducing inflammation and reversing DHT damage. The user is trialing these probiotics personally, ordering them from the U.S. to Canada, and plans to continue if no adverse effects occur.

community Better Than Minoxidil? Topical Sodium Valproate

in Research/Science 50 upvotes 4 months ago

Topical sodium valproate may promote hair growth by inhibiting GSK3β, allowing beta-catenin to proliferate, but it has potential side effects and requires more research. The conversation also mentions skepticism about a product called Vdphlo1, which includes sodium valproate and other ingredients.

community Has anyone used Magnesium L-Threonate ?

71 upvotes 6 years ago

Magnesium L-Threonate may help treat balding by reducing DKK-1 expression without affecting DHT. Users discuss its potential effectiveness and application methods, with some considering trying it topically.

community GT20029 and PP405 the new fin and min that we been waiting for ?

in Chat 36 upvotes 4 weeks ago

PP405 and GT20029 are new hair loss treatments with different mechanisms from traditional options like Minoxidil and Finasteride. PP405 targets hair follicle stem cells to reactivate growth, while GT20029 works as an androgen receptor deleter, both requiring ongoing use for effectiveness.

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