Regenerative Hair Waves in Aging Mice and Extra-Follicular Modulators Follistatin, Dkk1, and Sfrp4

March 2014 in “ Journal of Investigative Dermatology ”

Chih Chiang Chen, Philip J. Murray, Ting Jiang, Maksim V. Plikus, Yun Ting Chang, Oscar K. Lee, Randall B. Widelitz, Cheng Ming Chuong

hair follicle regeneration extra-follicular modulators Bmp2 Dkk1 Sfrp4 follistatin hair stem cells macroenvironment hair cycling stem cell depletion

Studysummary This study found that aging mice experience slower and more fragmented hair cycle waves, but transplanting aged skin to a young host can partially restore hair cycling, implicating extracellular factors.

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