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    Glossary Stem Cell Depletion

    reduction of stem cells impairing tissue regeneration and repair

    Stem cell depletion refers to the reduction or exhaustion of stem cells in a particular tissue or organ. This can lead to impaired tissue regeneration and repair, contributing to aging and various diseases, including hair loss conditions like alopecia. For professionals, it highlights the importance of maintaining stem cell populations for tissue homeostasis and the potential therapeutic targets for regenerative medicine.

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    Research 10 of 1000+

    1. Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis Cell Stem Cell · 2021 · 23 citations
    2. Epidermal Deletion of Rac1 Causes Stem Cell Depletion, Irrespective of whether Deletion Occurs during Embryogenesis or Adulthood Journal of Investigative Dermatology · 2007 · 18 citations
    3. Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss Cell Stem Cell · 2007 · 688 citations
    4. Gsdma3 Mutation Causes Bulge Stem Cell Depletion and Alopecia Mediated by Skin Inflammation American Journal Of Pathology · 2011 · 54 citations
    5. Mitochondrial deoxyguanosine kinase depletion induced ROS causes melanocyte stem cell exhaustion and hair greying Cell Regeneration · 2025
    6. Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability during Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1 Journal of Investigative Dermatology · 2012 · 1 citations
    7. Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability during Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1 Journal of Investigative Dermatology · 2012 · 72 citations
    8. LB965 Follicular trochanters: A potential mechanism for stem cell depletion in scarring alopecia 2020
    9. Major depletion of SOX2+ stem cells in the adult pituitary is not restored which does not affect hormonal cell homeostasis and remodelling Scientific Reports · 2017 · 22 citations
    10. Faculty Opinions recommendation of Hair follicle stem cell-specific PPARgamma deletion causes scarring alopecia. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2009
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    Community 10 of 185

    1. (/r/science X-post): Stress may turn your hair grey. The appearance of grey hairs after periods of stress or skin damage could be the result of depletion of stem cells from the base of the hair follicle, according to a new study : science Reddit · 10 Jun 2013
    2. Recent trials investigating mesenchymal stem cell derived exosomes demonstrate significant increases in anagen duration and hair shaft caliber by upregulating Wnt/beta-catenin pathways. Reddit · 24 Aug 2026
    3. PRP / laser / stem cell treatment before or after hair transplant – worth it? Reddit · 24 Aug 2026
    4. 42F: Has anyone tried stem-cell injections for hair loss? How was that? Reddit · 23 Aug 2026
    5. What do you guys think of stem cell hai restoration? Reddit · 23 Dec 2025
    6. PRP + Stem Cell Treatment For Hairloss Reddit · 14 Aug 2025
    7. Stem cell hair transplant? Any progress? Reddit · 31 Jan 2025
    8. PRP or Stem Cell therapy for hair growth? Reddit · 10 May 2024
    9. Mesenchymal Stem Cell Therapy (Exosome) Before & After Reddit · 9 Apr 2024
    10. Can anyone share experience with stem cell injections for hairloss? Reddit · 19 Dec 2023
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    Learn 3 of 13

    1. Hair Multiplication extract, clone, and reinsert your own hair cells
    2. Stem Cell Factor
    3. Apple stem cell
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