Apoptotic Dysregulation Mediates Stem Cell Competition and Tissue Regeneration

November 2023 in “ Nature Communications ”

Marianna Yusupova, Roi Ankawa, Yahav Yosefzon, David Meiri, Ido Bachelet, Yaron Fuchs

Bax protein hair follicle stem cells HFSCs apoptosis TNFα p65 hair follicle regeneration wound repair hypertrophic morphology tumor necrosis factor alpha hair stem cells

Studysummary This study reported that depleting the pro-apoptotic protein Bax in hair follicle stem cells enables these cells to kill nearby viable cells by sequestering TNFα, which increases the stem cell pool and accelerates tissue regeneration, suggesting potential implications for therapies targeting tissue repair and cancer.

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research May the Best Wound WIHN: The Hallmarks of Wound-Induced Hair Neogenesis

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This review discusses recent advancements in Wound Induced Hair Neogenesis in mice, emphasizing the potential of neogenic hair regeneration to enhance understanding of adult mammalian regeneration, but reports no new experimental results.

research Apoptotic Cells Represent a Dynamic Stem Cell Niche Governing Proliferation and Tissue Regeneration

25 citations , June 2021 in “Developmental Cell”

In this study, researchers found that deleting Caspase-9 in hair follicle stem cells delayed apoptosis, leading to accelerated wound repair and new hair follicle regeneration by maintaining apoptotic cells as signaling centers.

research Isolation of Stem Cells and Progenitors from Mouse Epidermis

13 citations , May 2017 in “Current Protocols in Stem Cell Biology”

This study outlines a method to isolate hair follicle stem cells from mouse skin using fluorescence activated cell-sorting for use in research models, but reports no experimental findings.

research Hair Follicle Stem Cell Cultures Reveal Self-Organizing Plasticity of Stem Cells and Their Progeny

61 citations , December 2016 in “The EMBO Journal”

This study established a new in vitro culture system that supports the growth and dynamic self-organization of hair follicle stem cells and their progeny, promoting a stable population equilibrium.

research Isolating Hair Follicle Stem Cells and Epidermal Keratinocytes from Dorsal Mouse Skin

23 citations , April 2016 in “Journal of Visualized Experiments”

This research details a robust method for isolating hair follicle stem cells and epidermal keratinocytes from mouse hair follicles using fluorescence activated cell-sorting technology.

research Sept4/ARTS Regulates Stem Cell Apoptosis and Skin Regeneration

78 citations , June 2013 in “Science”

This study found that mice lacking the Sept4/ARTS gene had more hair follicle stem cells and improved wound healing, suggesting apoptosis regulation as a potential target in regenerative medicine.

research Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration

6 citations , February 2013 in “Journal of Visualized Experiments”

This study introduces a method using lentiviral delivery in mice to expedite analysis of factors crucial for hair follicle morphogenesis by enabling rapid gain- or loss-of-function studies.

research Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis

503 citations , May 2009 in “Cell stem cell”

This study suggests that Lrig1-positive cells form a previously unknown reservoir of interfollicular epidermal stem cells in adult mouse skin, influencing epidermal proliferation and hair follicle development.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations , May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

research The Hair Cycle

375 citations , February 2006 in “Journal of Cell Science”

This article reviews the stages and regulation of the hair cycle, highlighting molecular regulators involved, but it does not present new research findings.

research Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis

1279 citations , November 2005 in “Nature Medicine”