Apoptotic Dysregulation Mediates Stem Cell Competition and Tissue Regeneration

    November 2023 in “ Nature Communications ”
    Marianna Yusupova, Roi Ankawa, Yahav Yosefzon … Yaron Fuchs
    Studysummary This study reported that depleting the pro-apoptotic protein Bax in hair follicle stem cells enables these cells to kill nearby viable cells by sequestering TNFα, which increases the stem cell pool and accelerates tissue regeneration, suggesting potential implications for therapies targeting tissue repair and cancer.
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    Research cited in this study 11

    1. May the Best Wound WIHN: The Hallmarks of Wound-Induced Hair Neogenesis Current Opinion in Genetics & Development · 2021
    2. Apoptotic Cells Represent a Dynamic Stem Cell Niche Governing Proliferation and Tissue Regeneration Developmental Cell · 2021
    3. Isolation of Stem Cells and Progenitors from Mouse Epidermis Current Protocols in Stem Cell Biology · 2017
    4. Hair Follicle Stem Cell Cultures Reveal Self-Organizing Plasticity of Stem Cells and Their Progeny The EMBO Journal · 2016
    5. Isolating Hair Follicle Stem Cells and Epidermal Keratinocytes from Dorsal Mouse Skin Journal of Visualized Experiments · 2016
    6. Sept4/ARTS Regulates Stem Cell Apoptosis and Skin Regeneration Science · 2013
    7. Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration Journal of Visualized Experiments · 2013
    8. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    9. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    10. The Hair Cycle Journal of Cell Science · 2006
    11. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005

    Related research 1

    1. Regeneration of Hair Follicles Is Modulated by Flightless I (Flii) in a Rodent Vibrissa Model Journal of Investigative Dermatology · 2010