Apoptotic Cells Represent a Dynamic Stem Cell Niche Governing Proliferation and Tissue Regeneration

    June 2021 in “ Developmental Cell ”
    Roi Ankawa, Nitzan Goldberger, Yahav Yosefzon … Yaron Fuchs
    Studysummary In this study, researchers found that deleting Caspase-9 in hair follicle stem cells delayed apoptosis, leading to accelerated wound repair and new hair follicle regeneration by maintaining apoptotic cells as signaling centers.
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    Research cited in this study 9

    1. Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing Nature Communications · 2018
    2. Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size Molecular Cell · 2018
    3. Isolation of Stem Cells and Progenitors from Mouse Epidermis Current Protocols in Stem Cell Biology · 2017
    4. Sept4/ARTS Regulates Stem Cell Apoptosis and Skin Regeneration Science · 2013
    5. Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin Nature Reviews Molecular Cell Biology · 2009
    6. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    7. The Hair Cycle Journal of Cell Science · 2006
    8. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    9. WNT Signaling in the Control of Hair Growth and Structure Developmental biology · 1999

    Related research 4

    1. Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate International Journal of Molecular Sciences · 2018
    2. Keratin 79 Identifies a Novel Population of Migratory Epithelial Cells That Initiates Hair Canal Morphogenesis and Regeneration Journal of Cell Science · 2013
    3. Regeneration of Hair Follicles Is Modulated by Flightless I (Flii) in a Rodent Vibrissa Model Journal of Investigative Dermatology · 2010
    4. Skin and Hair: Models for Exploring Organ Regeneration Human Molecular Genetics · 2008