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GlossaryWnt3

protein involved in cell signaling crucial for hair growth

Wnt3 is a protein that plays a crucial role in cell signaling pathways, which are essential for various developmental processes in the body, including the growth and maintenance of hair follicles. It is part of the Wnt family of proteins, which are involved in regulating cell fate, proliferation, and migration. In the context of hair biology, Wnt3 signaling is important for the activation and cycling of hair follicles, and disruptions in this pathway can contribute to conditions like alopecia (hair loss).

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Identification of Transcriptional Targets of Wnt/β-Catenin Signaling in Dermal Papilla Cells of Human Scalp Hair Follicles: EP2 Is a Novel Transcriptional Target of Wnt3a

research Identification of Transcriptional Targets of Wnt/β-Catenin Signaling in Dermal Papilla Cells of Human Scalp Hair Follicles: EP2 Is a Novel Transcriptional Target of Wnt3a

29 citations, March 2010 in “Journal of Dermatological Science”

Wnt3a activates certain genes in hair follicle cells, including a newly discovered one, EP2, which may affect hair growth.

research Isolation and Characterization of Recombinant Murine Wnt3a

3 citations, November 2014 in “Protein Expression and Purification”

Scientists successfully purified a protein called Wnt3a, which is involved in processes like hair growth, but the overall yield was low, suggesting more work is needed to improve this.

Hair Growth Is Promoted in Mouse Dorsal Skin by a Mixture of Platycladus Orientalis Leaf Extract and Alpha-Terpineol by Increasing Growth Factors and Wnt3/β-Catenin

research Hair Growth Is Promoted in Mouse Dorsal Skin by a Mixture of Platycladus Orientalis Leaf Extract and Alpha-Terpineol by Increasing Growth Factors and Wnt3/β-Catenin

2 citations, August 2020 in “Natural Product Communications”

A mix of Platycladus orientalis leaf extract and alpha-terpineol helps mice grow hair by increasing growth factors and cell growth.

research Exosomes Derived From Dermal Papilla Cells Mediate Hair Follicle Stem Cell Proliferation Through The Wnt3a/Beta-Catenin Signaling Pathway

2 citations, November 2022 in “Oxidative Medicine and Cellular Longevity”

Exosomes from dermal papilla cells help hair follicle stem cells grow and survive.

research A Bio-Functional Wnt3a Gradient Microarray for Cell Niche Studies

April 2023 in “Advanced functional materials”

The study created a tool that mimics natural cell signals, which increased cell growth and could help with hair regeneration research.

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community Better Than Minoxidil? Topical Sodium Valproate

in Research/Science 51 upvotes 1 month ago

Topical sodium valproate may promote hair growth by inhibiting GSK3β, allowing beta-catenin to proliferate, but it has potential side effects and requires more research. The conversation also mentions skepticism about a product called Vdphlo1, which includes sodium valproate and other ingredients.