Liposomal Honokiol Promotes Hair Growth Via Activating Wnt3a/β-Catenin Signaling Pathway and Downregulating TGF-β1 in C57BL/6N Mice

The study on C57BL/6N mice found that liposomal honokiol significantly promoted hair regrowth by activating the Wnt3a/β-catenin signaling pathway and downregulating TGF-β1 expression. This treatment facilitated the transition of hair follicles from the telogen to anagen stage, increased dermal thickness, and elevated the number of hair follicles, particularly between 14 and 21 days after treatment. The findings suggested that liposomal honokiol could be a promising therapeutic agent for alopecia by modulating key signaling pathways involved in hair follicle cycling, although further research was needed to fully understand its mechanisms.