Cold Atmospheric Microwave Plasma Stimulates Dermal Papilla Cell Proliferation by Inducing Beta-Catenin Signaling

The study investigated the effects of Cold Atmospheric Microwave Plasma (CAMP) on hair growth. It found that CAMP promotes the growth of human dermal papillary cells, essential for hair growth, by upregulating the protein expression of the β-catenin signaling pathway and YAP/TAZ. CAMP also prevents β-catenin degradation via USP47, a protein that inhibits β-catenin ubiquitination and promotes cell proliferation. Additionally, CAMP increases INPP5D mRNA expression and induces Akt and GSK-3β phosphorylation in dermal papillary cells, further promoting cell proliferation. CAMP was also found to induce a core aggregate configuration of dermal papillary cells with HaCaT keratinocytes, a crucial step for hair follicle induction. These findings suggest that CAMP could be a potential treatment for hair loss.