Keratinocytes Maintain Compartmentalization Between Dermal Papilla and Fibroblasts in 3D Heterotypic Tri-Cultures

    August 2019 in “ Cell Proliferation ”
    Justin Tan, John E.A. Common, Chunyong Wu … Lifeng Kang
    Studysummary This study found that 3D cultured hair follicle-like constructs, which include keratinocytes and dermal papilla cells, showed improved gene expression and cell interactions relevant to hair follicle development.
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    Research cited in this study 14

    1. Minoxidil Downregulates Interleukin-1 Alpha Gene Expression in HaCaT Cells International Journal of Trichology · 2018
    2. Impact of Substrate Stiffness on Dermal Papilla Aggregates in Microgels Biomaterials Science · 2018
    3. Differential Expression Between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia Journal of Investigative Dermatology · 2016
    4. Hair Growth-Promoting Effect of Carthamus Tinctorius Floret Extract Phytotherapy Research · 2013
    5. Microenvironmental Reprogramming by Three-Dimensional Culture Enables Dermal Papilla Cells to Induce De Novo Human Hair-Follicle Growth Proceedings of the National Academy of Sciences of the United States of America · 2013
    6. Follicular Dermal Papilla Structures by Organization of Epithelial and Mesenchymal Cells in Interfacial Polyelectrolyte Complex Fibers Biomaterials · 2013
    7. Fabrication of a 3D Hair Follicle-Like Hydrogel by Soft Lithography Journal of Biomedical Materials Research Part A · 2013
    8. Scalable Production of Controllable Dermal Papilla Spheroids on PVA Surfaces and the Effects of Spheroid Size on Hair Follicle Regeneration Biomaterials · 2012
    9. Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling Seminars in Cell & Developmental Biology · 2012
    10. The Mesenchymal Component of Hair Follicle Neogenesis: Background, Methods, and Molecular Characterization Experimental Dermatology · 2009
    11. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    12. Self-Assembly of Dermal Papilla Cells into Inductive Spheroidal Microtissues on Poly(Ethylene-Co-Vinyl Alcohol) Membranes for Hair Follicle Regeneration Biomaterials · 2008
    13. Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells Journal of Investigative Dermatology · 2005
    14. Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2003

    Related research 6

    1. Dermal Fibroblast Expression of LEF1 Is Critical to Normal Skin and Hair Development and Regenerative Wound Healing in Mice Journal of Investigative Dermatology · 2022
    2. Keratinocytes Maintain Compartmentalization Between Dermal Papilla and Fibroblasts in 3D Heterotypic Tri-Cultures Cell Proliferation · 2019
    3. Hair Follicle Units Improving the Construction of Tissue Engineered Skin In Vitro Journal of Tissue Engineering and Reconstructive Surgery · 2013
    4. Miz1 Is Required for Hair Follicle Structure and Hair Morphogenesis Journal of cell science · 2007
    5. Sheep Vibrissa Dermal Papillae Induce Hair Follicle Formation in Heterotypic Skin Equivalents British Journal of Dermatology · 1994
    6. The Dermal Papilla and Maintenance of Hair Growth 1988