Minoxidil Downregulates Interleukin-1 Alpha Gene Expression in HaCaT Cells

January 2018 in “ International Journal of Trichology ”

Erkin Pekmezci, Murat Türkoğlu, Hilal Gökalp, Zekayі Kutlubay

Minoxidil Interleukin-1 alpha IL-1α HaCaT cells androgenetic alopecia alopecia areata sulfotransferase activity hair follicles Rogaine skin cells male pattern baldness hair loss sulfotransferase

From the encyclopedia

Minoxidil →

An essential vasodilator with some anti-androgenic effects

Alopecia Areata →

autoimmune disorder causing patchy hair loss

Studysummary In this study, minoxidil significantly downregulated interleukin-1 alpha expression in human keratinocyte cells, suggesting an anti-inflammatory effect that may be a mechanism of action in treating alopecia.

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